Novel method for emboli analog formation towards improved stroke retrieval devices
Anne Preut1, Megan Laughlin1, Hanna Jensen1
1Department of Biomedical Engineering, University of Arkansas, Fayetteville, AR, United States.
Journal of Biomechanics
|September 27, 2018
Summary
Researchers developed a new method to create realistic stroke clot analogs by controlling rotation speed, improving retrieval device development. This technique better mimics the material properties and composition of actual cerebral thromboemboli.
Area of Science:
- Biomedical Engineering
- Materials Science
- Neuroscience
Background:
- Unsuccessful recanalization in stroke patients is linked to fibrin-rich clots.
- Current methods for creating clot analogs lack quantitative material properties and composition data.
- Developing effective stroke retrieval mechanisms requires accurate replication of cerebral thromboemboli properties.
Purpose of the Study:
- To investigate emboli analog (EA) formation to mimic cerebral thromboemboli.
- To replicate the material stiffness and composition of cerebral thromboemboli.
- To develop new stroke retrieval mechanisms.
Main Methods:
- Emboli analogs (EAs) were formed using porcine whole blood and calcium chloride at varying rotational speeds (0, 34, 50, 80 RPM).
- Histology and custom MATLAB code were used for composition analysis.
- Biomechanical testing quantified material stiffness for comparison with human thromboemboli.
Main Results:
- Increasing rotational speed increased fibrin/platelet content and material stiffness.
- EAs formed at 50 RPM showed material stiffness most similar to carotid endarterectomy (CEA) thromboemboli.
- Nonlinearity in biomechanical testing was observed in 11% of EAs, predominantly those formed statically.
Conclusions:
- Dynamically formed EAs can be modified to achieve desired fibrin/platelet to erythrocyte ratios.
- The proposed EA formation methodology provides a platform for advancing retrieval mechanism prototypes.
- This study offers a quantitative approach to replicating cerebral thromboemboli for improved stroke treatment device development.
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