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Related Experiment Video

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The Power of Interstimulus Interval for the Assessment of Temporal Processing in Rodents

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Using Temporal Expectation to Assess Auditory Streaming in Mice.

Gaëlle A Chapuis¹, Paul T Chadderton^1,2

¹Department of Bioengineering, Imperial College London, London, United Kingdom.

Frontiers in Behavioral Neuroscience

|September 27, 2018

Summary

This summary is machine-generated.

Mice can perceptually segregate complex sounds, a process called auditory streaming. This study developed a new task to measure this ability in mice, revealing insights into selective attention mechanisms.

Keywords:

auditory cortex (AC)false alarm (FA)psychoacoustic scene analysis selective attention top-down pathways

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Area of Science:

Neuroscience
Auditory Perception
Animal Behavior

Background:

Auditory streaming segregates environmental sound into distinct perceptual objects.
Understanding neuronal mechanisms of auditory streaming is limited by a lack of suitable non-primate behavioral paradigms.
Mice are valuable models for neural mechanism studies due to available genetic tools.

Purpose of the Study:

To develop and validate a novel behavioral task for assessing auditory streaming in head-fixed mice.
To investigate the neural basis of selective auditory attention in mice using this paradigm.

Main Methods:

A behavioral task where mice detect a target sound within one of two simultaneous pure tone sequences.
Manipulation of temporal expectation by varying target sound presentation timing within blocks.
Extracellular electrophysiological recordings during task performance.

Main Results:

Mice achieved high performance (d' > 1) in the auditory streaming task.
False alarm timing reflected temporal expectations and was timed to the target stream, indicating stream segregation.
Electrophysiology showed flexible modulation of sound processing aligned with behavioral outcomes.

Conclusions:

Auditory streaming perception can be inferred from false alarm timing in mice.
This novel paradigm enables investigation of the neuronal mechanisms underlying selective auditory attention in mice.