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Mass Spectrometry-Guided Genome Mining as a Tool to Uncover Novel Natural Products
Published on: March 12, 2020
Adenoviromics: Mining the Human Adenovirus Species D Genome
Ashrafali M Ismail1, Ji Sun Lee1, Jeong Yoon Lee1,2
1Howe Laboratory, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, United States.
Abstract:
Human adenovirus (HAdV) infections cause disease world-wide. Whole genome sequencing has now distinguished 90 distinct genotypes in 7 species (A-G). Over half of these 90 HAdVs fall within species D, with essentially all of the HAdV-D whole genome sequences generated in the last decade. Herein, we describe recent new findings made possible by mining of this expanded genome database, and propose future directions to elucidate new functional elements and new functions for previously known viral components.
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