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A Wilms' Tumor with Spinal Cord Compression: An Extrarenal Origin?
Audrey Petit1, Amandine Rubio1, Chantal Durand2
1Département de Pédiatrique, CHU de Grenoble, Grenoble, France.
Case Reports in Pediatrics
|September 27, 2018
Summary
Spinal cord compression from Wilms' tumor (WT) is rare. This case shows direct tumor spread through foramina causing compression, successfully treated with chemotherapy and surgery.
Area of Science:
- Pediatric Oncology
- Nephrology
- Neurology
Background:
- Spinal cord compression is a rare but serious complication of Wilms' tumor (WT).
- Most reported cases involve metastatic disease, unlike this case of direct contiguous spread.
Observation:
- A 3-year-old girl presented with spinal cord compression due to a tumor spreading through vertebral foramina.
- Imaging revealed an extrarenal tumor infiltrating the spinal canal via the T11-L1 and L1-L2 neural foramina.
Findings:
- The patient received urgent treatment with corticosteroids and chemotherapy, followed by a left nephrectomy.
- Histological examination confirmed an extrarenal Wilms' tumor (nephroblastoma) with regressive changes and intermediate risk.
Implications:
- This case highlights an unusual route of spinal cord compression in Wilms' tumor.
- Early diagnosis and prompt multimodal treatment are crucial for favorable outcomes in such rare presentations.