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Updated: Feb 4, 2026

An Efficient and Reproducible Protocol for Distraction Osteogenesis in a Rat Model Leading to a Functional Regenerated Femur
Published on: October 23, 2017
[Symphyseal bone distraction (part 2): which protocol in 2018? A systematic literature review]
Gabriel Lietz1, Sarah Gebeile-Chauty1
1Faculté d'Odontologie,rue Guillaume Paradin 69372 Lyon cedex 08, France.
Introduction:
The aim of this systematic literature review is to propose a clinical protocol in 2018 by comparing therapeutic efficacy and undesirable effects of the technique.
Materials And Methods:
Searches were made on Pubmed/Medline and Cochrane for randomized clinical trials and case series involving mandibular symphyseal distraction over the past 20 years with a patient sample greater than or equal to 10.
Results:
Of the 92 articles, 25 met the inclusion criteria. A controlled trial was selected, but no randomized trial. The other studies were all case series, 16 retrospective and 8 prospective. Dental crowding over 7 mm, with or without compensation, is an indication for mid-symphyseal distraction. Pre-surgical orthodontic treatment ensures root divergence between the mandibular incisors. Tooth-borne devices are recommended in first intention. Surgical intervention (ambulatory) under local anesthesia and intravenous sedation is considered. The latency period before activation of the jack is 6 days. Activations are performed by the orthodontist and subsequently by the patient at a rate of 1 mm per day, with four activations daily. Orthodontic movements are resumed two weeks after activations are discontinued. The distractor is removed within two to three months after installation.
Conclusion:
Although the main features of the mid-symphyseal distraction protocol were drawn up essentially in the light of expert opinion, they still need to be refined by controlled trials.
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