Furo[2,3- g]thieno[2,3- e]indole: Application of an Ynamide-Based Benzannulation Strategy to the Synthesis of a
Clarissa C Forneris1, Yu-Pu Wang1, Galina Mamaliga1
1Department of Chemistry , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States.
Abstract:
The first synthesis of the tetracyclic aromatic compound furo[2,3- g]thieno[2,3- e]indole ("FTI") is described. The synthetic strategy features a photochemical benzannulation based on the reaction of an α-diazo ketone and ynamide which assembles a benzothiophene equipped with substituents that enable subsequent cyclizations to generate the nitrogen and oxygen heterocyclic rings.
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