[Pathology of HPV-associated oropharyngeal squamous cell carcinoma]
1Sebészeti és Molekuláris Patológiai Osztály, Országos Onkológiai Intézet, Budapest, Hungary. erika66toth@gmail.com.
Abstract:
Over the past decade, human papillomavirus-related oropharyngeal squamous cell carcinoma has become a distinct entity that differs from conventional head and neck cancer in many ways including its epidemiology, genetics, tumor behavior, and prognosis. Human papillomavirus-related oropharyngeal squamous cell carcinomas also exhibit characteristic histologic features. This review will cover the histomorphologic appearances of human papillomavirus-related oropharyngeal carcinoma, with an emphasis on their differences from conventional, human papillomavirus-unrelated cancer. Besides these we summarize the mechanism of carcinogenesis and the last guidelines for diagnosing this type of cancers.
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