Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Base-Catalyzed Aldol Addition Reaction01:08

Base-Catalyzed Aldol Addition Reaction

4.6K
As depicted in Figure 1, base-catalyzed aldol addition involves adding two carbonyl compounds in aqueous sodium hydroxide to form a β-hydroxy carbonyl compound.
4.6K
Acid-Catalyzed Aldol Addition Reaction01:15

Acid-Catalyzed Aldol Addition Reaction

3.3K
The aldol reaction of a ketone under acidic conditions successfully forms an unsaturated carbonyl as the final product instead of an aldol. The acid-catalyzed aldol reaction is depicted in Figure 1.
3.3K
Acid-Catalyzed Ring-Opening of Epoxides02:24

Acid-Catalyzed Ring-Opening of Epoxides

9.0K
Epoxides that are three-membered ring systems are more reactive than other cyclic and acyclic ethers. The high reactivity of epoxides originates from the strain present in the ring. This ring strain acts as a driving force for epoxides to undergo ring-opening reactions either with halogen acids or weak nucleophiles in the presence of mild acid. The acid catalyst converts the epoxide oxygen, a poor leaving group, into an oxonium ion, a better leaving group, making the reaction feasible. The...
9.0K
Base-Catalyzed Ring-Opening of Epoxides02:26

Base-Catalyzed Ring-Opening of Epoxides

10.2K
Due to their highly strained structures, epoxides can readily undergo ring-opening reactions through nucleophilic substitution, either in the presence of an acid or a base. The nucleophilic substitution reactions in the presence of acid are called acid-catalyzed ring-opening reactions, and nucleophilic substitution reactions in the presence of a base are called base-catalyzed ring-opening reactions. Epoxides undergo base-catalyzed ring-opening reactions in the presence of a strong nucleophile...
10.2K
Acid-Catalyzed Dehydration of Alcohols to Alkenes02:35

Acid-Catalyzed Dehydration of Alcohols to Alkenes

24.0K
In a dehydration reaction, a hydroxyl group in an alcohol is eliminated along with the hydrogen from an adjacent carbon. Here, the products are an alkene and a molecule of water. Dehydration of alcohols is generally achieved by heating in the presence of an acid catalyst. While the dehydration of primary alcohols requires high temperatures and acid concentrations, secondary and tertiary alcohols can lose a water molecule under relatively mild conditions.
24.0K
Acid-Catalyzed Hydration of Alkenes02:45

Acid-Catalyzed Hydration of Alkenes

17.3K
Alkenes react with water in the presence of an acid to form an alcohol. In the absence of acid, hydration of alkenes does not occur at a significant rate, and the acid is not consumed in the reaction. Therefore, alkene hydration is an acid-catalyzed reaction.
17.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unveiling the variations in penile cancer care: identifying knowledge gaps and research priorities.

BMJ oncology·2026
Same author

Electrochemical synthesis of 2-oxa-bicyclo[2.1.1]hexanes by anodic oxidation-cyclization relay strategy.

Chemical science·2026
Same author

Clinical and surgical management of recto-urinary fistula after radical prostatectomy: a systematic review on current evidence.

Prostate cancer and prostatic diseases·2026
Same author

Enantioselective Pd-Catalyzed Electrochemical Dearomative Allylation of Tropones: Construction of All-C Quaternary Stereocenters.

Organic letters·2026
Same author

Diagnostic and treatment delays in penile cancer: a call to improve awareness and referral.

World journal of urology·2026
Same author

The Mucosal-sparing Augmented Non-Transected Anastomosis (MsANTA) principle for tubular organs.

BJU international·2026
Same journal

How Much Chirality is Enough?

Chimia·2026
Same journal

Raman Optical Activity (ROA) as an Emerging Standard in Molecular Chirality Measurements - A Perspective.

Chimia·2026
Same journal

Molecular Chirality: From Structure to the Quantum Dynamics of Tunnelling, Parity Violation, a Molecular Quantum Switch and the Possible Astrophysical Detection of Homochirality as a Signature of Extraterrestrial Life.

Chimia·2026
Same journal

Shining Light on Chiral Monolayer-protected Metal Clusters.

Chimia·2026
Same journal

Spin Depolarization Mechanisms in Halide Perovskite Semiconductors.

Chimia·2026
Same journal

New Insights into Circularly Polarized Luminescence from Chromium(III) Spin-Flip Emitters.

Chimia·2026
See all related articles

Related Experiment Video

Updated: Feb 4, 2026

Gold Nanoparticle Synthesis
13:42

Gold Nanoparticle Synthesis

Published on: July 10, 2021

15.9K

Gold-catalyzed Dearomatization Reactions.

Juzeng An1, Marco Bandini2

  • 1Dipartimento di Chimica "G. Ciamician" Alma Mater Studiorum - Università di Bologna Via Selmi 2, Bologna, Italy.

Chimia
|September 28, 2018
PubMed
Summary
This summary is machine-generated.

Homogenous gold catalysis offers new solutions for organic synthesis, particularly in dearomatization reactions. This review highlights recent advances in creating complex 3D molecules from aromatic compounds using gold catalysts.

More Related Videos

Using Flexible Gold-Titanium Reaction Cells to Simulate Pressure-Dependent Microbial Activity in the Context of Subsurface Biomining
13:11

Using Flexible Gold-Titanium Reaction Cells to Simulate Pressure-Dependent Microbial Activity in the Context of Subsurface Biomining

Published on: October 5, 2019

7.2K
Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions
11:44

Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions

Published on: March 20, 2014

25.9K

Related Experiment Videos

Last Updated: Feb 4, 2026

Gold Nanoparticle Synthesis
13:42

Gold Nanoparticle Synthesis

Published on: July 10, 2021

15.9K
Using Flexible Gold-Titanium Reaction Cells to Simulate Pressure-Dependent Microbial Activity in the Context of Subsurface Biomining
13:11

Using Flexible Gold-Titanium Reaction Cells to Simulate Pressure-Dependent Microbial Activity in the Context of Subsurface Biomining

Published on: October 5, 2019

7.2K
Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions
11:44

Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions

Published on: March 20, 2014

25.9K

Area of Science:

  • Organic Chemistry
  • Catalysis
  • Synthetic Methodology

Background:

  • Homogenous gold catalysis has transformed organic synthesis.
  • Dearomatization protocols are key for building complex 3D molecular scaffolds from 2D aromatic precursors.
  • Gold catalysis plays a significant role in dearomatization reactions.

Purpose of the Study:

  • To provide an overview of recent findings in homogenous gold-catalyzed dearomatization reactions.
  • To organize recent advances by the type of electrophilic partners used.
  • To showcase the utility of gold catalysis in synthesizing functionalized polycyclic scaffolds.

Main Methods:

  • Review of recent literature on homogenous gold catalysis.
  • Categorization of dearomatization reactions based on electrophilic partners.
  • Analysis of gold-catalyzed condensation reactions of arenes with hydrocarbons.

Main Results:

  • Gold catalysis enables the condensation of electron-rich arenes with various hydrocarbons.
  • These reactions lead to partial or total dearomatization of the aryl fragment.
  • A diverse range of functionalized polycyclic 3D-molecular scaffolds can be accessed.

Conclusions:

  • Homogenous gold catalysis is a powerful tool for dearomatization.
  • Recent advances have expanded the scope and efficiency of these reactions.
  • This methodology provides access to complex molecular architectures relevant to organic synthesis.