Related Experiment Video
Updated: Feb 4, 2026
06:33
Author Spotlight: Streamlined Brain and Skull Modeling for Enhanced Neurosurgical Planning in NHP Research
Published on: February 9, 2024
1.8K
Neuroprotective efficacy of P7C3 compounds in primate hippocampus
Melissa D Bauman1,2,3,4, Cynthia M Schumann5,6, Erin L Carlson5
1Department of Psychiatry and Behavioral Sciences, University of California, Davis, USA. mdbauman@ucdavis.edu.
Translational Psychiatry
|September 28, 2018
Summary
P7C3-A20, a compound enhancing neurogenesis, was tested in nonhuman primates. It safely protected neurons, suggesting potential for treating neuropsychiatric and neurodegenerative diseases in humans.
Area of Science:
- Neuroscience
- Pharmacology
- Drug Discovery
Background:
- Neuropsychiatric and neurodegenerative diseases require new therapeutics.
- P7C3 compounds enhance neurogenesis by protecting young neurons.
- Previous studies showed P7C3 efficacy in rodent models.
Purpose of the Study:
- To evaluate the neuroprotective efficacy and safety of P7C3-A20 in nonhuman primates.
- To compare P7C3-A20's proneurogenic effects with NSI-189 in mice.
Main Methods:
- Adult male rhesus monkeys received daily oral P7C3-A20 or vehicle for 38 weeks.
- 5'-bromo-2-deoxyuridine (BrdU) was injected to label newborn cells.
- Quantification of BrdU+ cells using unbiased stereology in primates and mice.
Main Results:
- P7C3-A20 showed sustained plasma exposure and was well-tolerated in primates.
- P7C3-A20 elevated the survival of hippocampal BrdU+ cells in nonhuman primates without adverse effects.
- In mice, P7C3-A20 promoted greater neurogenesis than NSI-189 by enhancing neuronal survival.
Conclusions:
- P7C3-A20 safely protects neurons in nonhuman primates.
- The neuroprotective efficacy of P7C3 compounds is likely translatable to humans.
- P7C3-A20 offers a promising therapeutic strategy for neurological disorders.
Related Concept Videos
01:29Self-Efficacy
230
Self-efficacy is the belief in one's capacity to organize and execute actions necessary to manage prospective situations. This belief significantly influences how individuals approach goals, tasks, and challenges across different domains of life.Psychological and Educational ImpactsIndividuals with strong self-efficacy are more resilient in the face of difficulties. They are more likely to adopt effective problem-solving strategies, persist through obstacles, and regulate emotions such as...
230
02:38Molecules and Compounds
68.8K
Atoms and Molecules
68.8K
01:19Role of Hippocampus in Memory
1.6K
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
1.6K
03:02Organic Compounds
57.5K
All living things are formed mostly of carbon compounds called organic compounds. The category of organic compounds includes both natural and synthetic compounds that contain carbon. Although a single, precise definition has yet to be identified by the chemistry community, most agree that a defining trait of organic molecules is the presence of carbon as the principal element, bonded to hydrogen and other carbon atoms. However, some carbon-containing compounds such as carbonates, cyanides, and...
57.5K
01:27Elements and Compounds
105.0K
Pure substances consist of only one type of matter. A pure substance can be an element or a compound. An element consists of only one type of atom, while a compound consists of two or more types of atoms held together by a chemical bond.
Elements
Elements are classified as atomic or molecular based on the nature of their basic units. They are unique forms of matter with specific chemical and physical properties that cannot break down into smaller substances by ordinary chemical reactions. There...
Elements
Elements are classified as atomic or molecular based on the nature of their basic units. They are unique forms of matter with specific chemical and physical properties that cannot break down into smaller substances by ordinary chemical reactions. There...
105.0K
02:55Solubility of Ionic Compounds
68.2K
Solubility is the measure of the maximum amount of solute that can be dissolved in a given quantity of solvent at a given temperature and pressure. Solubility is usually measured in molarity (M) or moles per liter (mol/L). A compound is termed soluble if it dissolves in water.
68.2K