Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Structures of Solids02:22

Structures of Solids

17.8K
Solids in which the atoms, ions, or molecules are arranged in a definite repeating pattern are known as crystalline solids. Metals and ionic compounds typically form ordered, crystalline solids. A crystalline solid has a precise melting temperature because each atom or molecule of the same type is held in place with the same forces or energy. Amorphous solids or non-crystalline solids (or, sometimes, glasses) which lack an ordered internal structure and are randomly arranged. Substances that...
17.8K
Factors Affecting Drug Distribution: Organ Perfusion Rate01:15

Factors Affecting Drug Distribution: Organ Perfusion Rate

604
Drug distribution within the body is a complex process influenced by several factors, including perfusion rate, the rate at which the bloodstream transports drugs to tissue. This limitation becomes particularly significant when dealing with highly lipophilic drugs. In such cases, the rate at which the drug can move across membranes is crucial, and if the membrane is highly permeable to the drug, distribution becomes rate-limited by perfusion.
Perfusion rate-limited distribution relies on the...
604
Metallic Solids02:37

Metallic Solids

20.7K
Metallic solids such as crystals of copper, aluminum, and iron are formed by metal atoms. The structure of metallic crystals is often described as a uniform distribution of atomic nuclei within a “sea” of delocalized electrons. The atoms within such a metallic solid are held together by a unique force known as metallic bonding that gives rise to many useful and varied bulk properties.
All metallic solids exhibit high thermal and electrical conductivity, metallic luster, and malleability....
20.7K
Network Covalent Solids02:18

Network Covalent Solids

16.2K
Network covalent solids contain a three-dimensional network of covalently bonded atoms as found in the crystal structures of nonmetals like diamond, graphite, silicon, and some covalent compounds, such as silicon dioxide (sand) and silicon carbide (carborundum, the abrasive on sandpaper). Many minerals have networks of covalent bonds.
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
16.2K
Comparative Excretory Systems02:24

Comparative Excretory Systems

26.7K
Animals have evolved different strategies for excretion, the removal of waste from the body. Most waste must be dissolved in water to be excreted, so an animal’s excretory strategy directly affects its water balance.
26.7K
Molecular and Ionic Solids02:54

Molecular and Ionic Solids

20.1K
Crystalline solids are divided into four types: molecular, ionic, metallic, and covalent network based on the type of constituent units and their interparticle interactions.
Molecular Solids
Molecular crystalline solids, such as ice, sucrose (table sugar), and iodine, are solids that are composed of neutral molecules as their constituent units. These molecules are held together by weak intermolecular forces such as London dispersion forces, dipole-dipole interactions, or hydrogen bonds, which...
20.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Graph Neural Networks for Medical Imaging Analysis and Biological Data: Integrating Topology, Geometry, Radiomics, and Generative AI.

Bioengineering (Basel, Switzerland)·2026
Same author

From complexity to clarity: aging bone marrow niche in bone and blood regeneration and malignancy.

Bone research·2026
Same author

Myoblast Therapy Ameliorates Skeletal Muscle Atrophy Resulting From Chronic Denervation.

Muscle & nerve·2026
Same author

Establishing the Fatty Acid Photodecarboxylase <i>Cv</i>FAP as a Platform for Photobiocatalytic Radical Transformations.

ACS catalysis·2026
Same author

Design and Synthesis of Peptide-Polyester Conjugates for Cell-Mediated Scaffold Degradation.

Advanced healthcare materials·2026
Same author

Chiari Decompression in Patients with Spontaneous Intracranial Hypotension: Presenting Symptoms and Treatment Response.

AJNR. American journal of neuroradiology·2026
Same journal

Chrysoeriol-Mediated Neuroprotection in Parkinson's Disease in Mice: Targeting Apoptosis, α-Synuclein Accumulation, and Functional Recovery.

The Yale journal of biology and medicine·2026
Same journal

Musicality is Preserved in Neurodegeneration.

The Yale journal of biology and medicine·2026
Same journal

Burden of Neurological Disorders in Resource-Limited Settings: Lessons from Pakistan for Global Neurology.

The Yale journal of biology and medicine·2026
Same journal

Comparative Analysis of Prenatal Stress Models: Placental and Neurodevelopmental Outcomes in Mice.

The Yale journal of biology and medicine·2026
Same journal

Computational Investigation of Flavonoid-Associated Molecular Pathways in Astrogliosis Modulation.

The Yale journal of biology and medicine·2026
Same journal

Regulation and Interaction Among SOCS1 and SOCS3 by MicroRNAs in Multiple Sclerosis: A Review and <i>In Silico</i> Analysis.

The Yale journal of biology and medicine·2026
See all related articles

Related Experiment Video

Updated: Feb 4, 2026

Innovative Strategies for Organ Preservation in Heart Transplantation: Uniform Cooling Preservation and Ex-situ Normothermic Perfusion
08:15

Innovative Strategies for Organ Preservation in Heart Transplantation: Uniform Cooling Preservation and Ex-situ Normothermic Perfusion

Published on: November 28, 2025

592

Advances in Perfusion Systems for Solid Organ Preservation.

Sara Salehi1,2, Kenny Tran1,2, Warren L Grayson1,2,3,4

  • 1Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD.

The Yale Journal of Biology and Medicine
|September 28, 2018
PubMed
Summary
This summary is machine-generated.

Organ preservation using near-normothermic perfusion systems offers a promising solution to the organ donor shortage. These advanced techniques aim to improve the viability of organs for transplantation, reducing long waiting lists for patients needing life-saving procedures.

Keywords:
Bioreactorsmesenchymal stem cell manufacturingtissue-on-a-chip

More Related Videos

Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion
08:54

Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion

Published on: April 27, 2015

17.4K
Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation
08:12

Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation

Published on: July 15, 2015

19.8K

Related Experiment Videos

Last Updated: Feb 4, 2026

Innovative Strategies for Organ Preservation in Heart Transplantation: Uniform Cooling Preservation and Ex-situ Normothermic Perfusion
08:15

Innovative Strategies for Organ Preservation in Heart Transplantation: Uniform Cooling Preservation and Ex-situ Normothermic Perfusion

Published on: November 28, 2025

592
Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion
08:54

Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion

Published on: April 27, 2015

17.4K
Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation
08:12

Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation

Published on: July 15, 2015

19.8K

Area of Science:

  • Medical Engineering
  • Transplantation Biology
  • Organ Preservation Science

Background:

  • Organ failure diagnosis historically led to poor patient outcomes.
  • Organ transplantation is now standard but faces donor shortages and long waiting lists.
  • Current cold storage methods for organ preservation have significant limitations.

Purpose of the Study:

  • To review recent advancements in perfusion systems for solid organ preservation.
  • To discuss the limitations of existing organ preservation techniques.
  • To highlight research on developing commercially available perfusion systems.

Main Methods:

  • Review of historical organ transplantation techniques.
  • Analysis of limitations in current cold storage and early perfusion systems.
  • Examination of emerging near-normothermic perfusion technologies for various organs.

Main Results:

  • Development of cold perfusion systems to overcome diffusional limitations.
  • Trend towards near-normothermic systems for enhanced functional preservation of livers, lungs, hearts, and kidneys.
  • Ongoing research focuses on creating viable commercial perfusion systems.

Conclusions:

  • Perfusion systems, particularly near-normothermic ones, are crucial for improving organ preservation.
  • Advancements in perfusion technology aim to increase the availability of transplantable organs.
  • The development of commercial perfusion systems is key to addressing organ donor shortages and recipient waiting lists.