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Tocilizumab in Large Vessel Vasculitis - Different Routes of Administration
Marc Schmalzing1, Ottar Gadeholt1, Michael Gernert1
1Focus on Rheumatology / Clinical Immunology, Department of Internal Medicine II, University of Würzburg, 97080 Wurzburg, Germany.
The Open Rheumatology Journal
|September 28, 2018
Summary
Tocilizumab effectively treats large vessel vasculitis in real-world use, showing acceptable safety despite potential infectious risks. Switching to intravenous administration can help manage relapses in patients on subcutaneous tocilizumab.
Area of Science:
- Rheumatology
- Immunology
- Pharmacology
Background:
- Tocilizumab is increasingly utilized for large vessel vasculitis (LVV).
- Recent approval for giant cell arteritis (GCA) highlights its growing role.
Purpose of the Study:
- To assess tocilizumab's real-world efficacy and safety in LVV.
- To evaluate different administration routes for tocilizumab in LVV.
Main Methods:
- Retrospective analysis of LVV patients treated with tocilizumab.
- Involved patients from a tertiary rheumatology department.
Main Results:
- 11 LVV patients (8 GCA, 2 RA-associated LVV, 1 Takayasu arteritis) received tocilizumab.
- 7 patients achieved remission with low-dose prednisone; 3 relapses occurred under continuous treatment.
- Switching to intravenous tocilizumab resolved relapses in 3 patients.
Conclusions:
- Tocilizumab demonstrates efficacy in real-world LVV management.
- Safety is generally acceptable, though infectious complications require monitoring.
- Intravenous tocilizumab is a viable option for managing subcutaneous treatment relapses.
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