Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

18.4K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
18.4K
Association Areas of the Cortex01:21

Association Areas of the Cortex

9.4K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
9.4K
Associative Learning01:27

Associative Learning

1.3K
Associative learning is a fundamental concept in behavioral psychology, wherein a connection is established between two stimuli or events, leading to a learned response. This process is critical in understanding how behaviors are acquired and modified. Conditioning, the mechanism through which associations are formed, can be divided into two main types: classical conditioning and operant conditioning, each elucidating different aspects of associative learning.
Classical conditioning, also known...
1.3K
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

720
Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
720
Somatosensory, Motor, and Association Cortex01:23

Somatosensory, Motor, and Association Cortex

2.7K
The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at...
2.7K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

15.7K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
15.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Revisiting Chromosomal Translocations: Insights From Healthy Individuals and Lymphoma.

The journal of applied laboratory medicine·2025
Same author

Bioinformatic analysis of KIT juxtamembrane domain mutations in Syrian GIST patients: jigsaw puzzle completed.

Journal of the Egyptian National Cancer Institute·2023
Same author

Salivary-Based Cell-Free Mitochondrial DNA Level Is an Independent Prognostic Biomarker for Patients with Head and Neck Squamous Cell Carcinoma.

Journal of personalized medicine·2023
Same author

EBV Plasma Epstein-Barr Virus (EBV) DNA as a Biomarker for Diagnosis of EBV-positive Hodgkin Lymphoma in Syria.

Journal of infection in developing countries·2022
Same author

Polymorphism of IFN-γ (+874 T/A) in Syrian patients with chronic hepatitis B.

Gastroenterology and hepatology from bed to bench·2017
Same author

Seropositivity of Hepatitis B and C among Syrian Multi-transfused Patients with Hemoglobinopathy.

Mediterranean journal of hematology and infectious diseases·2016
Same journal

SLE and Serum Complement: Causative, Concomitant or Coincidental?

The open rheumatology journal·2018
Same journal

Losartan, but not Enalapril and Valsartan, Inhibits the Expression of IFN-γ, IL-6, IL-17F and IL-22 in PBMCs from Rheumatoid Arthritis Patients.

The open rheumatology journal·2018
Same journal

Tocilizumab in Large Vessel Vasculitis - Different Routes of Administration.

The open rheumatology journal·2018
Same journal

Plasma Saturated and Monounsaturated Fatty Acids in Behçet's Disease.

The open rheumatology journal·2018
Same journal

Assessment of Mean Platelet Volume in Patients with Systemic Lupus Erythematosus.

The open rheumatology journal·2018
Same journal

Pamidronate Treatment of Osteonecrosis of the Hip in Young Male.

The open rheumatology journal·2018
See all related articles

Related Experiment Video

Updated: Feb 1, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

1.2K

Association Between STAT4 rs7574865 Polymorphism and Rheumatoid Arthritis: Debate Unresolved.

Iman Tarakji1, Wafa Habbal2, Fawza Monem1,2

  • 1Department of Biochemistry and Microbiology, Faculty of Pharmacy, Damascus University, Damascus, Syria.

The Open Rheumatology Journal
|December 4, 2018
PubMed
Summary
This summary is machine-generated.

The STAT4 rs7574865 polymorphism showed a potential link to Anti-Citrullinated Protein Antibodies (ACPA) positivity in Syrian Rheumatoid Arthritis (RA) patients. However, its overall impact on RA onset and severity appears minor compared to other genetic factors.

Keywords:
ACPAMHCRheumatoid arthritisSNPSTAT4 rs7574865Syria

More Related Videos

Generation of Induced-pluripotent Stem Cells Using Fibroblast-like Synoviocytes Isolated from Joints of Rheumatoid Arthritis Patients
09:31

Generation of Induced-pluripotent Stem Cells Using Fibroblast-like Synoviocytes Isolated from Joints of Rheumatoid Arthritis Patients

Published on: October 16, 2016

9.9K
Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis
06:31

Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis

Published on: October 6, 2023

3.1K

Related Experiment Videos

Last Updated: Feb 1, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

1.2K
Generation of Induced-pluripotent Stem Cells Using Fibroblast-like Synoviocytes Isolated from Joints of Rheumatoid Arthritis Patients
09:31

Generation of Induced-pluripotent Stem Cells Using Fibroblast-like Synoviocytes Isolated from Joints of Rheumatoid Arthritis Patients

Published on: October 16, 2016

9.9K
Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis
06:31

Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis

Published on: October 6, 2023

3.1K

Area of Science:

  • Genetics
  • Immunology
  • Rheumatology

Background:

  • The STAT4 rs7574865 polymorphism is linked to Rheumatoid Arthritis (RA) susceptibility in some populations.
  • Previous studies show conflicting results in different ethnic groups.

Purpose of the Study:

  • To investigate the STAT4 rs7574865 polymorphism distribution in Syrian RA patients.
  • To analyze the association between this polymorphism and ACPA status in RA.

Main Methods:

  • Genotyping of STAT4 rs7574865 via direct sequencing in 81 RA patients and 40 healthy controls.
  • Stratification of RA patients based on ACPA status for detailed analysis.

Main Results:

  • No significant differences in allele or genotype frequencies were observed between ACPA-positive RA patients, ACPA-negative RA patients, and healthy controls.
  • Minor T allele frequencies were 30.4% (ACPA+), 16.7% (ACPA-), and 23.8% (controls).

Conclusions:

  • The STAT4 rs7574865 TT genotype may influence ACPA positivity in Syrian RA patients.
  • The genetic contribution of STAT4 rs7574865 to RA onset and severity is likely minor, with HLA-DRB1 alleles being more significant.