Clinical Characteristics, Treatment Outcomes and Predictive Factors in Optic Neuritis

Area of Science:

• Ophthalmology
• Neurology
• Immunology

Background:

• Optic neuritis presentation and outcomes vary across populations.
• Accurate diagnosis of optic neuritis is vital for effective patient management.

Purpose of the Study:

• To identify clinical characteristics of optic neuritis.
• To determine treatment outcomes in patients with and without demyelinating diseases.
• To find predictive factors for treatment success in optic neuritis.

Main Methods:

• Retrospective descriptive study of 150 optic neuritis patients (2009-2016).
• Analysis included univariate and multivariate logistic regression.
• Evaluation of predictive factors for treatment outcomes.

Main Results:

• Neuromyelitis Optica Spectrum Disease (NMOSD) and idiopathic cases were more frequent than Multiple Sclerosis (MS).
• Younger age at presentation and NMOSD diagnosis correlated with poorer visual outcomes.
• Good visual outcomes were linked to better initial visual acuity and idiopathic cases.

Conclusions:

• NMOSD is more prevalent than MS in Thai optic neuritis patients.
• Female patients with poor initial vision, steroid response, and recurrent attacks may have NMOSD.
• Optic neuritis without demyelinating disease shows better visual prognosis and lower recurrence.