Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Negative Regulator Molecules01:23

Negative Regulator Molecules

38.5K
Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
38.5K
Positive, Negative, and Zero Work00:58

Positive, Negative, and Zero Work

22.2K
Work is done on an object when energy is transferred to the object. In other words, work is done when a force acts on a body that undergoes a displacement from one position to another. By definition, the work done by a force is the integral of the force with respect to the displacement along its path. Forces can vary as a function of position, and displacements can occur along various paths between two points. The magnitude of a force multiplied by the cosine of the angle that the force makes...
22.2K
Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

580
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
580
Responses to Gravity and Touch02:26

Responses to Gravity and Touch

41.9K
Gravitropism: Plant Responses to Gravity
41.9K
Positive and Negative Feedback Loops01:18

Positive and Negative Feedback Loops

25.3K
Animal organs and organ systems constantly adjust to internal and external changes through a process called homeostasis ("steady state"). Examples of these changes include regulation of the level of glucose or calcium in the blood or internal responses to external temperatures. Homeostasis requires  maintaining an internal dynamic equilibrium:
25.3K
Gram-negative Bacterial Protein Secretion Systems01:17

Gram-negative Bacterial Protein Secretion Systems

945
Gram-negative bacteria utilize sophisticated protein secretion systems to transport proteins across their double-membrane envelope into the extracellular environment or host cells. Based on their mechanism of action, these systems are classified into one-step and two-step pathways.One-Step Secretion Systems (Types I, III, IV, and VI)One-step secretion systems bypass the periplasm entirely, forming a continuous channel that spans both the inner and outer membranes:Type I Secretion System (T1SS):...
945

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Histopathologic Findings and Knowledge Gaps in Glaucomatous Neurodegeneration.

The American journal of pathology·2026
Same author

Expert consensus on fundus fluorescein angiography reporting in ophthalmology: a Delphi study.

The British journal of ophthalmology·2026
Same author

Intraocular pressure induced blood retinal barrier compromise in mouse models and human glaucoma.

Nature communications·2026
Same author

Geographic Atrophy on Fundus Autofluorescence and Color Fundus Photographs: Association with Deep Visual Sensitivity Losses.

Ophthalmology science·2026
Same author

Pediatric native and transplant kidney biopsies: complications and risk factors.

Pediatric nephrology (Berlin, Germany)·2026
Same author

Discrepancies between Fundus Photography and Multimodal Imaging in Mapping of Choroidal Tumor Borders.

Ophthalmology science·2026

Related Experiment Video

Updated: Feb 4, 2026

Isolation of Double Negative αβ T Cells from the Kidney
06:56

Isolation of Double Negative αβ T Cells from the Kidney

Published on: May 16, 2014

12.9K

Baseline Detrending for the Photopic Negative Response.

Jessica Tang1,2, Flora Hui1,2, Michael Coote1,2

  • 1Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.

Translational Vision Science & Technology
|September 28, 2018
PubMed
Summary

Baseline detrending methods significantly improve the repeatability of the photopic negative response (PhNR) in glaucoma patients. This enhancement maintains diagnostic accuracy, making PhNR a more reliable marker for retinal ganglion cell function.

Keywords:
baseline detrendingelectroretinogramglaucomaphotopic negative response

More Related Videos

Development of a Negative Selectable Marker for Entamoeba histolytica
06:05

Development of a Negative Selectable Marker for Entamoeba histolytica

Published on: December 12, 2010

12.8K
Isolation and Chemical Characterization of Lipid A from Gram-negative Bacteria
12:57

Isolation and Chemical Characterization of Lipid A from Gram-negative Bacteria

Published on: September 16, 2013

32.8K

Related Experiment Videos

Last Updated: Feb 4, 2026

Isolation of Double Negative αβ T Cells from the Kidney
06:56

Isolation of Double Negative αβ T Cells from the Kidney

Published on: May 16, 2014

12.9K
Development of a Negative Selectable Marker for Entamoeba histolytica
06:05

Development of a Negative Selectable Marker for Entamoeba histolytica

Published on: December 12, 2010

12.8K
Isolation and Chemical Characterization of Lipid A from Gram-negative Bacteria
12:57

Isolation and Chemical Characterization of Lipid A from Gram-negative Bacteria

Published on: September 16, 2013

32.8K

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Biomedical Engineering

Background:

  • The photopic negative response (PhNR) is a promising objective marker for retinal ganglion cell function.
  • Improving PhNR repeatability is crucial for its clinical application in diagnosing glaucoma.

Purpose of the Study:

  • To compare different baseline detrending methods for electroretinogram (ERG) recordings.
  • To enhance the repeatability of the PhNR without compromising its diagnostic utility in glaucoma detection.

Main Methods:

  • Photopic ERGs were recorded from glaucoma patients and controls using the RETeval device.
  • Detrending techniques included adjusting high-pass filters and applying polynomial trend removal.
  • Repeatability (COR%) and diagnostic ability (AUC) were assessed to compare methods.

Main Results:

  • Most detrending methods improved PhNR test-retest repeatability compared to standard ISCEV filtering.
  • Polynomial detrending (order 3) applied to the whole signal yielded the best repeatability (COR% ± 44%).
  • This method maintained diagnostic ability comparable to standard filtering (AUC 0.74 vs. 0.75).

Conclusions:

  • Baseline detrending effectively enhances PhNR repeatability for glaucoma assessment.
  • Careful selection of detrending methods is essential to avoid waveform distortion and preserve diagnostic value.
  • Further research into advanced processing techniques is warranted.