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Related Experiment Video

Updated: Mar 10, 2026

Quantitative Fundus Autofluorescence for the Evaluation of Retinal Diseases

Quantitative Fundus Autofluorescence for the Evaluation of Retinal Diseases

Published on: March 11, 2016

Geographic Atrophy on Fundus Autofluorescence and Color Fundus Photographs: Association with Deep Visual Sensitivity

Erin E Gee¹, Robyn H Guymer^1,2, Barbara A Blodi³

¹Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.

Ophthalmology Science

|March 9, 2026

Summary

Color fundus photograph (CFP) and fundus autofluorescence (FAF) defined geographic atrophy (GA) lesions smaller than 650 μm do not consistently indicate vision loss. Larger GA lesions are needed to reliably predict functional deficits.

Keywords:

Age-related macular degeneration Color fundus photography Fundus autofluorescence Geographic atrophy Microperimetry

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Area of Science:

Ophthalmology
Retinal Imaging
Visual Electrophysiology

Background:

Geographic atrophy (GA) is a leading cause of vision loss.
Accurate assessment of GA lesion size and functional impact is crucial for clinical trials.

Purpose of the Study:

To evaluate the functional characteristics of GA lesions defined by CFP and FAF.
To determine the prevalence of visual sensitivity defects in CFP- and FAF-defined GA.

Main Methods:

High-density microperimetry was used to assess visual sensitivity in regions with GA.
Readers assessed CFP and FAF images for GA and performed annotations.
OCT imaging confirmed retinal pigment epithelium and outer retinal atrophy.

Main Results:

CFP- and FAF-defined GA lesions ≥175 μm showed a repeatable sensitivity defect in 77%, 67%, and 62% of cases, respectively.
Only larger lesions (CFP-GA1 ≥625 μm, CFP-GA2 ≥650 μm, FAF-GA ≥675 μm) demonstrated a ≥90% prevalence of repeatable defects.
Smaller GA lesions did not consistently correlate with significant visual function loss.

Conclusions:

CFP- and FAF-defined GA lesions <650 μm do not reliably reflect non-responding test locations.
Larger GA lesion sizes are required to ensure functional characteristics similar to non-responding areas.
These findings are critical for selecting appropriate atrophic endpoints in clinical studies.