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Tissue Engineering of a Human 3D in vitro Tumor Test System
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3D tissue engineering, an emerging technique for pharmaceutical research.

Gregory Jensen1, Christian Morrill1, Yu Huang1

  • 1Department of Biological Engineering, Utah State University, Logan, UT, 84322, USA.

Acta Pharmaceutica Sinica. B
|September 28, 2018
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Summary
This summary is machine-generated.

Tissue engineering models show promise for treating neurodegenerative diseases by modulating central nervous system inflammation. Advances in scaffold properties and decellularized extracellular matrix offer new therapeutic avenues.

Keywords:
3D cell cultureDecellularizationDrug screeningNeurodegenerative diseaseNeuroinflammationTissue engineering

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Area of Science:

  • Biomedical Engineering
  • Neuroscience
  • Regenerative Medicine

Background:

  • Central nervous system (CNS) inflammation exacerbates neurodegenerative diseases like Alzheimer's and Parkinson's.
  • Inflammation hinders neural cell regeneration and causes functional loss in conditions such as traumatic brain injury.
  • Current treatments for neurodegenerative diseases have limitations in addressing underlying inflammatory processes.

Purpose of the Study:

  • To review recent advancements in tissue engineering models for neurodegenerative disease treatment.
  • To explore the modification of scaffold biophysical and biochemical properties for therapeutic applications.
  • To discuss the potential of decellularized extracellular matrix as an innovative scaffold material.

Main Methods:

  • Review of literature on tissue engineering strategies for CNS applications.
  • Analysis of studies altering scaffold properties (biophysical and biochemical) for neuroinflammation treatment.
  • Examination of extracellular matrix decellularization techniques and their use in regenerative scaffolds.

Main Results:

  • Tissue engineering models offer potential for improved drug delivery, action, and discovery in pharmaceutical research.
  • Tailoring scaffold properties can effectively attenuate CNS inflammatory responses.
  • Decellularized extracellular matrix presents a promising biomaterial for neurodegenerative disease therapies.

Conclusions:

  • Tissue engineering, particularly with modified scaffolds and decellularized matrix, holds significant therapeutic potential for neurodegenerative diseases.
  • Further research into scaffold optimization is crucial for enhancing regenerative capabilities and functional recovery.
  • This approach offers a novel strategy to combat neuroinflammation and its detrimental effects on neural tissue.