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Cerenkov Luminescence Imaging CLI for Cancer Therapy Monitoring
Published on: November 13, 2012
Clostridium novyi-NT in cancer therapy
Verena Staedtke1,2, Nicholas J Roberts1,3, Ren-Yuan Bai4
1Ludwig Center for Cancer Genetics and Therapeutics, The Johns Hopkins Sidney Kimmel Cancer Center, Baltimore, MD 21287, USA.
Abstract:
The attenuated anaerobic bacterium Clostridium novyi-NT (C. novyi-NT) is known for its ability to precisely germinate in and eradicate treatment-resistant hypoxic tumors in various experimental animal models and spontaneously occurring canine sarcomas. In this article, we review the therapeutic and toxicologic aspects of C. novyi-NT therapy, key challenges and limitations, and promising strategies to optimize its performance via recombinant DNA technology and immunotherapeutic approaches, to establish C. novyi-NT as an essential tool in cancer therapy.
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