Related Experiment Video

Updated: Feb 4, 2026

Translational Orthotopic Models of Glioblastoma Multiforme
07:37

Translational Orthotopic Models of Glioblastoma Multiforme

Published on: February 17, 2023

3.7K

Temozolomide resistance in glioblastoma multiforme

Sang Y Lee1

  • 1Department of Neurosurgery, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.

Genes & Diseases
|September 28, 2018
PubMed

Keywords:
AGT (also known as MGMT), O6-methylguanine-DNA alkyltransferaseAP-1, activator protein 1APE1, apurinic/apyrimidine endonuclease/redox factor-1APNG, Alkylpurine-DNA-N-glycosylaseAdaptiveBBB, blood-brain-barrierBCRP1, breast cancer resistance protein 1BER, base excision repairBG, benzylguanineC8orf4, Chromosome 8 open reading frame 4EGFR, epidermal growth factor receptorERK1/2, Extracellular Signal Regulated Kinases 1 and 2FDA, Food and Drug AdministrationGBM, glioblastoma multiforme or glioblastomaGlioblastomaHDAC, histone deacetylaseIFN-β, Interferon-βIntrinsicJNK, Jun N-terminal kinaseKDM, Histone lysine demethylaseLC50, 50% cell death concentrationLIF, Leukemia inhibitory factorMGMT, O6-methylguanine methyltransferaseMMR, DNA mismatch repairMSH6, mutS homolog 6MTIC, 5-(3-methyltriazen-1-yl) imidazole-4-carboxamideNAMPT, nicotinamide phosphoribosyl transferaseNF-κB, nuclear factor-Kappa BNHA, normal human astrocytesPARP, poly ADP ribose polymeraseResistanceSAHA, N-hydroxy-N′-phenyl-octanediamideSTAT3, Signal Transducer and Activator of Transcription 3TMZ, TemozolomideTNFAIP3, Tumor necrosis factor-α-induced protein 3TemodarTemozolomideVPA, Valproic acidmTOR, mammalian target of rapamycin

More Related Videos

Stereotactic Intracranial Implantation and In vivo Bioluminescent Imaging of Tumor Xenografts in a Mouse Model System of Glioblastoma Multiforme10:52

Stereotactic Intracranial Implantation and In vivo Bioluminescent Imaging of Tumor Xenografts in a Mouse Model System of Glioblastoma Multiforme

Published on: September 25, 2012

26.5K
Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment09:02

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment

Published on: September 27, 2024

3.2K

Related Concept Videos

Resistivity01:22

Resistivity

When a voltage is applied to a conductor, an electrical field is generated, and charges in the conductor feel the force due to the electrical field. The current density that results depends on the electrical field and the properties of the material. In some materials, including metals at a given temperature, the current density is approximately proportional to the electrical field. In these cases, the current density can be modeled as:
4.6K
Resistance01:19

Resistance

When a current moves through any conductor, the conductor causes some level of difficulty for the current to flow. The measure of that difficulty is known as the resistance of the material and is represented by R. Every material has its own resistance. In the case of conductors, heat is emitted whenever a current passes through them. Resistance depends on the resistivity of the material. Resistivity is a characteristic of the material used to fabricate electrical components, whereas the...
6.0K
Equivalent Resistance01:16

Equivalent Resistance

In circuit analysis, situations often arise where resistors are neither in series nor parallel configurations. To tackle such scenarios, three-terminal equivalent networks like the wye (Y) (Figure 1 (a)) or tee (T) and delta (Δ) (Figure 1 (b)) or pi (π) networks come into play. These networks offer versatile solutions and are frequently encountered in various applications, including three-phase electrical systems, electrical filters, and matching networks.
985
Resistance and Conductance01:25

Resistance and Conductance

A conductor's DC resistance at a given temperature is influenced by its resistivity, length, and cross-sectional area. Resistivity is an inherent property of the conductor material, with annealed copper serving as the international standard for measurement. For instance, the resistivity of hard-drawn aluminum at 20 degrees Celsius is 61% of the standard conductivity of annealed copper.
Various factors impact the resistance of a conductor. Spiraling in stranded conductors increases their...
517
Rolling Resistance01:21

Rolling Resistance

When a solid cylinder rolls steadily on a rigid surface, the normal force applied by the surface on the cylinder is perpendicular to the tangent at the contact point. However, since no materials are entirely rigid, the surface's reaction to the cylinder involves a range of normal pressures.
For instance, imagine a hard cylinder rolling on a comparatively soft surface. The cylinder's weight compresses the surface beneath it. As the cylinder moves, the material in front of it slows down due to...
665
Vascular Resistance01:20

Vascular Resistance

Vascular resistance is a critical concept in understanding blood flow dynamics in the circulatory system. It refers to the resistance that blood encounters as it flows through the blood vessels. This resistance is a key factor in determining blood pressure and cardiac workload.
The primary determinants of vascular resistance are vessel diameter, blood viscosity, and vessel length. Among these, vessel diameter plays the most significant role due to the fourth power relationship described by...
11.0K