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Updated: Feb 4, 2026
Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
Data on nasal eosinophil positive rates in childhood asthma on each age
Norihide Murayama1, Kikuno Murayama1
1Murayama Paediatrics, 3-2-33 Nagayoshi-Nagahara-Higashi, Hirano-ku, Osaka-shi, 547-0013 Osaka, Japan.
Insights
Nasal eosinophil testing can help diagnose allergic asthma in children. Positive rates increase with age, showing a correlation with other asthma risk factors in young patients.
Area of Science:
- Pediatric Allergy and Immunology
- Respiratory Medicine
Background:
- Nasal eosinophil examination is standard for diagnosing eosinophilic rhinitis.
- Its utility in diagnosing childhood allergic asthma requires further investigation.
Purpose of the Study:
- To evaluate the diagnostic value of nasal discharge eosinophils for childhood allergic asthma.
- To analyze age-related changes in positive rates and correlations with risk factors.
Main Methods:
- Retrospective analysis of 180 infants and young children with recurrent respiratory symptoms.
- Categorization into asthma and non-asthma groups based on symptoms and bronchodilator response.
- Examination of nasal discharge eosinophils and correlation with other predictive factors.
Main Results:
- Significantly higher positive rates of nasal eosinophils were observed in older children compared to infants (0-1 year).
- No significant differences in positive rates were found between the 0-1-year-old group and older groups across all asthma patient cohorts.
- Nasal discharge eosinophils correlated with other predictive factors for persistent asthma.
Conclusions:
- Nasal eosinophil examination shows potential utility in diagnosing childhood allergic asthma, with increasing positive rates in older age groups.
- The findings suggest a correlation between nasal eosinophils and other asthma risk factors, warranting further research into their interplay.
Abstract:
Nasal eosinophil examination is routine for the diagnosis of nasal eosinophil-positive rhinitis in patients with rhinorrhea symptoms. This retrospective data investigated whether testing for nasal discharge eosinophils is useful for diagnosing childhood allergic asthma, and changes of positive rates by each age. Infants and young children (n = 180) with at least 3 recurrent episodes at intervals of ≥ 1 week of respiratory symptoms and bronchodilator inhalation improvements, were divided into an asthma group and a non-asthma group, and the presence or absence of nasal discharge eosinophils was examined by age. Correlations between nasal discharge eosinophils and other predictive factors for persistent asthma were also examined. The evaluation of nasal discharge eosinophils in the asthma group showed a significantly high positive rate in older age groups than in the 0-1-year-old age group (p< 0.05-0.001). However, none of the asthma patient groups had any significant changes between the 0-1-year-old group and older groups. This pattern was similar for other risk factors, showing correlations between nasal discharge eosinophils and other predictive factors.
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