Related Experiment Video
Updated: Feb 4, 2026

Direct Mouse Trauma/Burn Model of Heterotopic Ossification
Published on: August 6, 2015
Comparison of Heterotopic Ossification After Fixed- and Mobile-Core Cervical Disc Arthroplasty
Junfeng Zeng1, Hao Liu1, Hua Chen1
1Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
Objective:
To compare the heterotopic ossification (HO) between cervical disc arthroplasty (CDA) with fixed- and mobile-core prosthesis and to compare the clinical and radiographic outcomes.
Methods:
This was a retrospective analysis of patients who underwent CDA in our institute. Patients were divided into a fixed-core group (Prodisc-C and Discover disc) and mobile-core group (Bryan and Prestige-LP disc). HO was assessed based on the McAfee classification. The visual analogue scale, Neck Disability Index, and Japanese Orthopaedic Association scores were used to evaluate clinical outcomes. In addition, radiographic assessments included cervical sagittal alignment (C2-C7 angle), segmental angle, and range of motion of the index level.
Results:
A total of 218 patients were included with a minimal follow-up of 24 months. There were 137 patients in mobile-core group (Prestige-LP, 102; Bryan, 35) and 81 patients in the fixed-core group (Discover, 43; and Prodisc-C, 38). The mean follow-up time was 46.8 months. At the final follow-up, the overall incidence of HO was 39.9%. The incidence of HO in the fixed-core group was significantly greater than that in the mobile-core group (50.6% vs. 33.6%, P = 0.013). However, there were no significant differences in visual analogue scale, Neck Disability Index, or Japanese Orthopaedic Association scores, C2-C7 angle, segmental angle, or range of motion of the index level between the 2 groups.
Conclusions:
The fixed-core prosthesis had a greater incidence of HO than mobile-core prosthesis after CDA. However, both CDA with fixed- and mobile-core prostheses obtained good clinical outcomes and maintained cervical sagittal alignment.
Related Concept Videos
The Nucleosome Core Particle
The paradox
Nucleosomes, paradoxically, perform two opposite functions simultaneously. On the one hand, their main responsibility is to protect the delicate DNA strands from physical damage and help achieve a higher compaction ratio. While on the other hand, they must allow polymerase enzymes to access DNA...
The Nucleosome Core Particle
Nucleosomes, paradoxically, perform two opposite functions simultaneously. On the one hand, their primary aim is to protect the delicate DNA strands from physical damage and help achieve a higher compaction ratio. On the other hand, they must allow polymerase enzymes to access histone-bound DNA during...
The Sense of Self: Reflected Self-Appraisal and Social Comparison
Bone Formation by Intramembranous Ossification
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
Fixed Action Patterns
Bone Formation by Endochondral Ossification

