Clear Cell Acanthoma on the Areola.

Area of Science:

• Dermatology
• Oncology

Background:

• Clear cell acanthoma (CCA) is a rare benign skin neoplasm typically affecting the lower extremities.
• While generally lacking racial or gender predilection, CCA on the breast is exceptionally uncommon, primarily reported in young Korean women.

Observation:

• This report details a rare instance of CCA occurring on the areola of an elderly woman.
• The lesion presented as a pink plaque with central erosions, initially raising concern for cutaneous metastasis due to a history of metastatic renal cell carcinoma.

Findings:

• Excisional biopsy confirmed the diagnosis of CCA, revealing characteristic pale, glycogenated epithelium.
• Post-operative follow-up for 6 months showed no recurrence or new lesion development.

Implications:

• Clinicians should include CCA in the differential diagnosis for new eczematous breast lesions, particularly in patients with a history of malignancy.
• This case broadens the clinical presentation spectrum of CCA, underscoring the importance of histopathological examination for accurate diagnosis.