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Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
Published on: December 1, 2016
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Anticancer Activity of Cynomorium coccineum
Mouna Sdiri1,2,3, Xiangmin Li4,5, William W Du6,7
1Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, ON M4N 3M5, Canada. sdiri.mouna88@gmail.com.
Cancers
|September 29, 2018
Summary
Cynomorium coccineum extracts show potent anticancer activity by inhibiting cancer cell viability and tumor growth. This study highlights Cynomorium as a promising source for developing new antineoplastic compounds.
Area of Science:
- Pharmacology and Phytochemistry
- Cancer Biology and Therapeutics
Background:
- Cynomorium species are known for bioactive metabolites and pharmacological applications.
- Previous studies reported various biological activities, but antitumor effects remain unclear.
- This research investigates the anticancer potential of Cynomorium coccineum and Cynomorium songaricum.
Purpose of the Study:
- To screen Cynomorium extracts for cytotoxic effects against various cancer cell lines.
- To elucidate the mechanism of action for the antitumor activity of Cynomorium coccineum.
- To evaluate the in vivo efficacy of Cynomorium coccineum extracts in a murine cancer model.
Main Methods:
- Cytotoxicity screening of three extracts from C. coccineum and C. songaricum against five cancer cell lines.
- In vitro assays assessing colony formation, cell cycle progression (G1 phase arrest), and viability of murine cancer cell lines.
- In vivo studies involving B16 murine cancer cell line inoculation and peritoneal injection of C. coccineum water extract.
Main Results:
- Water and alcohol extracts of C. coccineum demonstrated high efficacy in reducing cancer cell viability, even at low concentrations.
- In vitro studies showed inhibited cell cycle progression and colony formation, with ethanol extract inducing G1 phase accumulation.
- In vivo treatment significantly prolonged mouse survival, reduced tumor growth, and was associated with c-myc down-regulation and Foxo3 overexpression.
Conclusions:
- Cynomorium coccineum extracts exhibit significant antiproliferative and antitumor activities.
- The mechanism involves induction of programmed cell death, cell cycle arrest, and modulation of key gene expressions.
- Cynomorium plants represent a valuable source for novel antineoplastic drug discovery.
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