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Twelve-Step Asymmetric Synthesis of (-)-Nodulisporic Acid C
Nicole A Godfrey1, Devon J Schatz1, Sergey V Pronin1
1Department of Chemistry , University of California, Irvine , Irvine , California 92697-2025 , United States.
Abstract:
A short, enantioselective synthesis of (-)-nodulisporic acid C is described. The route features two highly diastereoselective polycyclizations en route to the terpenoid core and the indenopyran fragment and a highly convergent assembly of a challenging indole moiety. Application of this chemistry allows for a 12-step synthesis of the target indoloterpenoid from commercially available material.
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