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The significance of thrombophilia in paediatric thromboembolism

Sofie Sommer Hedegaard1, Anna Christina Klein2, Anne-Mette Hvas2,3

  • 1a Department of Paediatrics , Herning Regional Hospital , Herning , Denmark.

Scandinavian Journal of Clinical and Laboratory Investigation
|September 29, 2018
PubMed

Insights

Thrombophilia is linked to venous, not arterial, thrombosis in children. Testing for thrombophilia is recommended for pediatric venous thromboembolism cases.

Area of Science:

  • Pediatric Hematology
  • Thromboembolic Disease Research
  • Clinical Risk Factor Analysis

Background:

  • The role of thrombophilia in pediatric thromboembolic disease is debated.
  • Identifying risk factors for thrombosis in children is crucial for effective management.

Purpose of the Study:

  • To investigate the prevalence of thrombophilia and other risk factors in children experiencing thromboembolic events.
  • To determine the association between thrombophilia and arterial versus venous thrombosis in pediatric patients.

Main Methods:

  • Systematic review of medical records and laboratory results for 126 children (≤15 years) with recent thromboembolic events.
  • Analysis of thrombosis types (arterial vs. venous) and presence of hereditary or acquired thrombophilia.
  • Comparison of thrombophilia prevalence with the general population.

Main Results:

  • Out of 126 children, 99 (79%) had arterial thrombosis, and 27 (21%) had venous thrombosis.
  • Thrombophilia was found in 11% of children with arterial thrombosis (non-significant) and 33% with venous thrombosis (significant).
  • Acute illness or underlying diseases were present in 38% of children prior to the thromboembolic event.

Conclusions:

  • Thrombophilia is significantly associated with venous thromboembolism in children, but not arterial thrombosis.
  • Acute illness and underlying conditions appear to be significant risk factors for pediatric thromboembolic disease.
  • Thrombophilia testing is supported for children diagnosed with venous thromboembolism.

Keywords:
Childinfantnewbornstrokethromboembolismthrombophilia

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