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Biomarker-driven and molecular targeted therapies for colorectal cancers

Marta Schirripa1, Stacey A Cohen2, Francesca Battaglin1

  • 1Division of Medical Oncology 1, Istituto Oncologico Veneto, IRCCS, Padova, Italy.

Seminars in Oncology
|September 29, 2018
PubMed

Insights

Biomarker-driven therapies are improving metastatic colorectal cancer treatment. This review covers key biomarkers like RAS, BRAF, Her2, and MSI, exploring their role in patient selection and targeted treatment strategies.

Area of Science:

  • Oncology
  • Genetics

Background:

  • Metastatic colorectal cancer (mCRC) treatment has advanced with new strategies.
  • Biomarker-driven therapies are crucial for personalized mCRC treatment.

Purpose of the Study:

  • To review the role of key biomarkers in mCRC.
  • To discuss prognostic and predictive value of biomarkers.
  • To explore biomarker-driven treatment options for mCRC.

Main Methods:

  • Literature review of prognostic and predictive biomarkers in mCRC.
  • Analysis of RAS, BRAF mutations, Her2 amplification, microsatellite instability (MSI), and CpG island methylator phenotype (CIMP).

Main Results:

  • RAS and BRAF mutations impact treatment selection.
  • Her2 amplification is an emerging target.
  • MSI and CIMP status influence prognosis and treatment response.

Conclusions:

  • Biomarkers are essential for optimizing mCRC patient selection.
  • Targeted therapies based on biomarkers are transforming mCRC care.
  • Further research into novel biomarkers will enhance treatment strategies.
Keywords:
BRAFCpG island methylator phenotypeHER2Microsatellite instabilityRAS

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