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p53 and transformation by SV40.

D R O'Reilly

    Biology of the Cell
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    SV40 large T antigen immortalizes cells and promotes tumor formation by inducing DNA synthesis. Its ability to bind and stabilize cellular p53 protein is key to its oncogenic and transforming activities.

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    Area of Science:

    • Molecular Biology
    • Oncology
    • Virology

    Background:

    • SV40 large T antigen is known to immortalize and transform cells, potentially causing tumors.
    • T antigen induces cellular DNA synthesis, a likely mechanism in its oncogenesis.
    • The cellular protein p53 is involved in cell cycle control and is implicated in transformation.

    Purpose of the Study:

    • To review the transforming activities of SV40 large T antigen and p53.
    • To discuss the significance of p53 binding in T antigen-mediated cell transformation.

    Main Methods:

    • Literature review of studies on SV40 T antigen and p53.
    • Analysis of the molecular mechanisms underlying T antigen's oncogenic properties.
    • Discussion of the role of p53 stabilization in cellular transformation.

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    Main Results:

    • SV40 large T antigen binds specifically to and stabilizes the p53 protein.
    • p53 plays a critical role in regulating cell cycle progression from G0 to G1 and S phases.
    • Altered p53 expression is linked to transformed cell phenotypes and immortalization.

    Conclusions:

    • T antigen's ability to bind and stabilize p53 may be responsible for its transforming potential.
    • Understanding the interaction between T antigen and p53 is crucial for comprehending viral oncogenesis.
    • This interaction highlights p53 as a central player in the transformation process induced by SV40.