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[АNTISEPTICS: MODERN STRATEGY OF STRUGGLE WITH CAUSING AGENTS OF THE ІNFECTION COMPLICATIONS]

O A Nazarchuk

    Klinichna Khirurhiia
    |September 29, 2018
    PubMed

    Insights

    In severe burn patients, Staphylococcus aureus and Acinetobacter baumannii are key pathogens. Antiseptic solutions and antimicrobial dressings effectively combat these infections, aiding burn wound management.

    Area of Science:

    • Infectious Diseases
    • Burn Care
    • Microbiology

    Background:

    • Infective complications pose a significant threat to patients with severe burns.
    • Identifying the primary etiological agents is crucial for effective treatment strategies.

    Purpose of the Study:

    • To investigate the etiology of infectious complications in severe burn patients.
    • To evaluate the efficacy of various antimicrobial agents and dressing materials.

    Main Methods:

    • Microbiological analysis of causative agents in 71 burn patients.
    • Determination of microbial resistance to common antibiotics.
    • In vitro and clinical assessment of antiseptic solutions and antimicrobial dressings.

    Main Results:

    • Staphylococcus aureus (35.9%) and Acinetobacter baumannii (25%) were the predominant pathogens.
    • Significant resistance was observed against cephalosporins, aminoglycosides, imipenem, meropenem, and doxycycline.
    • Antiseptic solutions (decasan, miramistinum, chlorhexidine) demonstrated effective bactericidal activity.
    • Dressings with decametoxine, chlorhexidine, furagin, and silver ions showed high antimicrobial properties against Staphylococcus.
    • Materials impregnated with decametoxine, carboxymethylstarch, oxyethylcellulose, and polyvinyl acetate proved clinically effective for prophylaxis and treatment.

    Conclusions:

    • Effective management of burn-related infections requires understanding the prevalent pathogens and their resistance patterns.
    • Antimicrobial dressings and antiseptic solutions offer promising therapeutic options for preventing and treating infectious complications in burn patients.

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