Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment01:08

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

280
Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
280
Hepatic Portal System01:21

Hepatic Portal System

6.0K
The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is...
6.0K
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

245
Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
245
Hepatic Drug Excretion: Influencing Factors01:16

Hepatic Drug Excretion: Influencing Factors

589
The biliary system of the liver, crucial for bile secretion and drug excretion, comprises intrahepatic bile ducts that merge to form the common hepatic duct. This duct, carrying hepatic bile, combines with the cystic duct, draining the gallbladder and forming the common bile duct, which empties into the duodenum. Bile, produced by hepatic cells lining the bile canaliculi, is composed primarily of water, bile salts, pigments, electrolytes, and lesser amounts of cholesterol and fatty acids. Bile...
589
Hepatic Drug Clearance: Role of Transporters01:14

Hepatic Drug Clearance: Role of Transporters

310
In the liver and bile canaliculi, influx and efflux transporters modification can influence intrinsic clearance. Transporters play a significant role in moving drugs within liver cells. Elaborate models, such as the Biopharmaceutical Classification System (BCS), are essential to relate transporters to drug disposition. This system categorizes drugs into four classes based on solubility and permeability, providing insights into elimination routes and the effects of transporters following oral...
310
Hepatic Drug Excretion: Enterohepatic Cycling01:17

Hepatic Drug Excretion: Enterohepatic Cycling

2.8K
Enterohepatic cycling involves the active secretion of drugs and their metabolites into the bile via transporters in the canalicular membrane of hepatocytes. This secretion is an integral part of the digestive process, releasing these substances into the gastrointestinal (GI) tract.
Post-release drugs and metabolites can be reabsorbed into the body from the intestine. For conjugated metabolites like glucuronides, reabsorption requires enzymatic hydrolysis by intestinal microflora. This...
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[DYNAMICS OF HEPATIC BLOOD FLOW IN IMMEDIATE PERIOD AFTER PREOPERATIVE EMBOLIZATION OF A PORTAL VEIN].

Klinichna khirurhiia·2016
Same author

[ROENTGEN-ENDOVASCULAR EMBOLIZATION OF THE PORTAL VEIN BRANCHES AS A PATIENTS CONDITIONING FOR EXTENSIVE HEPATIC RESECTION].

Klinichna khirurhiia·2015
Same author

[IMMUNOLOGICAL FACTORS OF THE INNATE IMMUNITY IN PATIENTS WITH HEPATOCELLULAR CARCINOMA OF A LARGE SIZE].

Klinichna khirurhiia·2015
Same author

[Results of preoperative embolization of portal vein in patients with biliary hepatic tumors].

Klinichna khirurhiia·2015
Same author

[Preoperative portal vein embolization: dynamics of portal pressure].

Klinichna khirurhiia·2014
Same author

[The treatment of hepatic artery stenosis after orthotopic transplantation of hepatic right lobe from a live relative donor].

Klinichna khirurhiia·2013

Related Experiment Video

Updated: Feb 4, 2026

Monitoring of Systemic and Hepatic Hemodynamic Parameters in Mice
16:09

Monitoring of Systemic and Hepatic Hemodynamic Parameters in Mice

Published on: October 4, 2014

17.1K

[STATE OF HEPATIC HEMODYNAMICS IN TRANSPLANTATION OF ITS RIGHT PART WITH MEDIAN HEPATIC VEIN].

O G Kotenko, A A Minich, A V Gusyev

    Klinichna Khirurhiia
    |September 29, 2018
    PubMed
    Summary

    This study examined regional hemodynamics after liver transplantation, finding that portal blood flow peaked on day two and decreased by day four. Post-transplant hepatic blood flow changes reflect reduced vascular resistance and improved venous outflow.

    More Related Videos

    Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure
    16:19

    Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure

    Published on: September 13, 2014

    13.2K
    Laparoscopic Anatomic S7+S8d Resection Preserving Inferior Right Hepatic Vein and S6 with Right Hepatic Vein Transection
    06:00

    Laparoscopic Anatomic S7+S8d Resection Preserving Inferior Right Hepatic Vein and S6 with Right Hepatic Vein Transection

    Published on: December 30, 2025

    303

    Related Experiment Videos

    Last Updated: Feb 4, 2026

    Monitoring of Systemic and Hepatic Hemodynamic Parameters in Mice
    16:09

    Monitoring of Systemic and Hepatic Hemodynamic Parameters in Mice

    Published on: October 4, 2014

    17.1K
    Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure
    16:19

    Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure

    Published on: September 13, 2014

    13.2K
    Laparoscopic Anatomic S7+S8d Resection Preserving Inferior Right Hepatic Vein and S6 with Right Hepatic Vein Transection
    06:00

    Laparoscopic Anatomic S7+S8d Resection Preserving Inferior Right Hepatic Vein and S6 with Right Hepatic Vein Transection

    Published on: December 30, 2025

    303

    Area of Science:

    • Hepatology
    • Vascular Surgery
    • Transplant Medicine

    Background:

    • Liver transplantation, particularly of the right hepatic part with the median hepatic vein, requires careful assessment of regional hemodynamics.
    • Understanding postoperative blood flow patterns is crucial for optimizing graft function and patient outcomes.

    Purpose of the Study:

    • To investigate the peculiarities of regional hemodynamics following transplantation of the right hepatic part with the median hepatic vein.
    • To analyze key blood flow parameters and their temporal changes in the early postoperative period.

    Main Methods:

    • Utilized ultrasonographic flowmetry in 31 patients undergoing liver transplantation.
    • Measured volume portal blood flow (VPBF), linear speed of blood flow (LSBF), and resistance index (RI) in the hepatic artery.
    • Assessed the phasic structure of blood flow in hepatic veins.

    Main Results:

    • Maximal VPBF was observed on postoperative day two, with a minimum on day four.
    • Hepatic artery blood flow initially increased, peaking on day two, then decreased by day four.
    • Altered phasic structure of hepatic vein blood flow was noted in 38% of patients postoperatively.

    Conclusions:

    • Post-transplant changes in hepatosplanchnic blood flow are attributed to reduced vascular resistance.
    • Improvements in venous outflow and enhanced regenerative activity of the transplanted liver segment are key outcomes.
    • These hemodynamic shifts are vital indicators of successful graft integration and function.