Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Disaggregation of bone into crystals.

S Weiner, P A Price

    Calcified Tissue International
    |December 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Bone mineral crystals are plate-shaped and their size and arrangement depend on their association with collagen. This challenges previous ideas about bone structure and collagen-mineral interactions.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    In vivo imaging of dorsal root ganglia in the mouse: from ex vivo MR-microscopy towards quantitative in vivo MRI.

    Brain research·2025
    Same author

    The use of ultrasound imaging in aesthetic injectables: A modified Delphi consensus.

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2025
    Same author

    Dorsal Root Ganglion Volumetry by MR Gangliography.

    AJNR. American journal of neuroradiology·2022
    Same author

    Training in Bariatric Surgery: a National Survey of German Bariatric Surgeons.

    Obesity surgery·2019
    Same author

    [Barriers to the German Society for General and Visceral Surgery (DGAV) accreditation "Center for bariatric and metabolic surgery"].

    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2018
    Same author

    [Quality indicators for metabolic and bariatric surgery in Germany : Evidence-based development of an indicator panel for the quality of results, indications and structure].

    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2017
    Same journal

    ODAPH (p.Arg77*) Phenotype and Onset of Ameloblast Pathology During Postsecretory Transition Demonstrated by FIB-SEM Analyses of Odaph<sup>C41*/C41*</sup> Mice.

    Calcified tissue international·2026
    Same journal

    Cytokine Networks Reprogramming the Osteo-Immune Microenvironment in Cancer Bone Metastasis.

    Calcified tissue international·2026
    Same journal

    Associations between controlling nutritional status and mortality in osteoporosis: evidence from NHANES, 2005-2018.

    Calcified tissue international·2026
    Same journal

    Gut Microbiota-Derived TMAO Drives MC3T3-E1 Senescence and Osteogenic Dysfunction via cGAS-STING-NF-κB Signaling: Implications for Age-Related Bone Loss.

    Calcified tissue international·2026
    Same journal

    Artificial Intelligence Approaches for Osteoporotic Fracture Risk Prediction Using Administrative Health Data: A Systematic Review.

    Calcified tissue international·2026
    Same journal

    The Important Role of Polycystin in the Skeletal System.

    Calcified tissue international·2026
    See all related articles

    Area of Science:

    • Biomineralization
    • Bone Biology
    • Materials Science

    Background:

    • Bone's mechanical properties depend on the organization of its mineral and organic phases.
    • Understanding crystal structure and collagen-mineral interactions is key to bone health.

    Purpose of the Study:

    • To investigate the sizes, shapes, and organizational states of bone mineral crystals.
    • To clarify the relationship between collagen fibrils and mineral crystals in bone.

    Main Methods:

    • Systematic disaggregation of bone's mineral phase via chemical oxidation and sonication.
    • Separation of crystal aggregates and monomers using gravity sedimentation in ethanol.
    • Comparative analysis of six different bone samples.

    Main Results:

    Related Experiment Videos

    • Bone crystals are tabular or plate-shaped.
    • Crystals intimately associated with collagen fibrils disaggregate into monomers.
    • Crystals in dense bone, located between fibrils, form "fused" aggregates.
    • Crystal dimensions (length < 450 Å, width ~250 Å) exceed collagen gap region diameters.

    Conclusions:

    • The one-crystal-per-gap-region model for bone collagen-mineral interaction is incorrect.
    • A reevaluation of the relationship between collagen and mineral in bone is required.
    • Crystal organization significantly influences bone's structural integrity.