Related Experiment Video

Updated: Feb 4, 2026

Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats
09:37

Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats

Published on: August 1, 2018

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Cirrhosis and Portal Hypertension in the Pediatric Population

Catherine A Chapin1, Lee M Bass1

  • 1Division of Pediatric Gastroenterology, Hepatology and Nutrition, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, 225 East Chicago Avenue, Box #65, Chicago, IL 60611, USA.

Clinics in Liver Disease
|September 30, 2018
PubMed

Insights

Cirrhosis, a liver condition, can lead to portal hypertension in children. This review covers causes, complications like varices and ascites, and treatments for pediatric portal hypertension.

Area of Science:

  • Hepatology
  • Pediatric Gastroenterology

Background:

  • Cirrhosis involves liver architectural changes and nodule formation.
  • Cirrhosis is a common precursor to portal hypertension.
  • Portal hypertension in children has diverse etiologies.

Purpose of the Study:

  • To review the causes of pediatric portal hypertension.
  • To discuss complications such as gastroesophageal varices and ascites.
  • To explore extrahepatic manifestations and treatment options for portal hypertension.

Main Methods:

  • Literature review of pediatric portal hypertension.
  • Synthesis of information on etiologies and complications.
  • Overview of current treatment strategies.

Main Results:

  • Identified common causes: extrahepatic portal vein obstruction, biliary atresia, alpha 1 antitrypsin deficiency, autoimmune hepatitis.
  • Highlighted gastroesophageal varices and ascites as significant complications.
  • Summarized extrahepatic manifestations and therapeutic interventions.

Conclusions:

  • Pediatric portal hypertension requires understanding its varied causes and serious complications.
  • Effective management involves addressing both intrahepatic and extrahepatic aspects.
  • Further research into optimal treatment strategies is warranted.

Keywords:
AscitesBiliary atresiaChildrenCirrhosisEsophageal varicesPortal hypertension

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