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Liver Transplantation in Children

Yen H Pham1, Tamir Miloh2

  • 1Pediatric Gastroenterology, Hepatology, and Nutrition, Baylor College of Medicine, Texas Children's Hospital, 18200 Katy Freeway, Suite 250, Houston, TX 77094, USA.

Clinics in Liver Disease
|September 30, 2018
PubMed

Insights

Pediatric liver transplantation (LT) offers excellent survival rates for children with liver disease or tumors. This lifesaving procedure significantly enhances quality of life, covering indications to post-transplant care.

Area of Science:

  • Pediatric Hepatology
  • Transplant Surgery
  • Immunology

Background:

  • Liver transplantation (LT) is a critical intervention for pediatric patients facing end-stage liver disease, hepatic malignancies, and certain metabolic disorders.
  • Successful LT in children ensures long-term patient and graft survival, dramatically improving quality of life.

Purpose of the Study:

  • To provide a comprehensive overview of pediatric liver transplantation.
  • To detail the unique considerations and processes involved in pediatric LT.

Main Methods:

  • Review of current literature and clinical practices in pediatric LT.
  • Discussion of key elements including indications, patient selection, organ allocation, surgical techniques, and post-operative management.

Main Results:

  • Pediatric LT demonstrates high rates of short- and long-term success.
  • The procedure is vital for improving survival and quality of life in pediatric patients with severe liver conditions.

Conclusions:

  • Pediatric liver transplantation is a well-established, life-saving treatment with excellent outcomes.
  • A multidisciplinary approach encompassing all stages from evaluation to long-term care is crucial for successful pediatric LT.

Keywords:
ImmunosuppressionLiver failureLiving donorPediatric liver transplantSplit liver

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