Head and Neck Cancer Research and Support Foundations

Area of Science:

• Oncology
• Genetics
• Epigenetics

Background:

• Squamous cell mucosal lesions, both dysplastic and malignant, present a significant challenge in head and neck cancer.
• Current research focuses on identifying novel biomarkers and therapeutic targets for improved patient outcomes.

Purpose of the Study:

• To investigate ongoing genetic and epigenetic research for the identification and treatment of squamous cell mucosal lesions.
• To explore strategies for enhancing immunotherapy response rates.
• To assess the potential of metformin in managing oral squamous cell dysplastic lesions.

Main Methods:

• Analysis of DNA methylation patterns.
• Salivary biomarker identification.
• Evaluation of wild-type p53 tumor suppressor gene proteins.
• Investigation of HPV oncogenes.
• Tumor microenvironment modulation for immunotherapy.
• Application of metformin for lesion management.

Main Results:

• Ongoing research is identifying key genetic and epigenetic factors in squamous cell lesions.
• Strategies to increase tumor microenvironment inflammation are being explored to improve immunotherapy.
• Metformin is under investigation for its role in preventing and managing oral squamous cell dysplastic lesions.

Conclusions:

• Genetic and epigenetic research holds promise for the diagnosis and treatment of head and neck cancers.
• Enhancing tumor inflammation and exploring repurposed drugs like metformin are key areas for advancing cancer therapy.
• Collaboration with cancer support organizations is vital for research progress.