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Growth Hormone Therapy in Heart Failure
Andrea Salzano1, Alberto M Marra2, Roberta D'Assante2
1Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre, University of Leicester, Glenfield Hospital, Leicester, LE3 9QP, UK; Department of Translational Medical Sciences, Federico II University, School of Medicine, Via Pansini 5, Naples, 80131, Italy.
Heart Failure Clinics
|September 30, 2018
Summary
Growth hormone (GH) deficiency is common in chronic heart failure, impacting function and outcomes. This review explores GH deficiency, its effects, and the potential of GH-replacement therapy in heart failure patients.
Area of Science:
- Cardiology
- Endocrinology
- Heart Failure Research
Background:
- Growth hormone (GH) deficiency is prevalent in chronic heart failure (CHF).
- GH deficiency correlates with reduced functional capacity and poorer prognosis in CHF patients.
- Animal models suggest GH treatment benefits cardiovascular parameters and survival.
Purpose of the Study:
- To assess growth hormone (GH) deficiency in chronic heart failure (CHF).
- To review the molecular basis, clinical impact, and therapeutic strategies for GH deficiency in CHF.
- To discuss the evolving role of GH-replacement therapy in managing CHF.
Main Methods:
- Review of existing literature on GH deficiency in chronic heart failure.
- Analysis of data from animal models and clinical studies.
- Exploration of molecular mechanisms and therapeutic outcomes.
Main Results:
- Clinical translation of GH treatment benefits in CHF has yielded inconsistent results.
- Understanding the molecular background of GH deficiency is crucial for effective management.
- GH-replacement therapy presents a promising avenue for improving outcomes in CHF.
Conclusions:
- GH deficiency is a significant comorbidity in chronic heart failure.
- Further research is needed to clarify the role and optimize GH-replacement therapy in CHF.
- Targeted GH therapy may offer improved functional capacity and outcomes for select CHF patients.
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