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Updated: Feb 4, 2026

A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats
Published on: March 1, 2022
Management of Pulmonary Hypertension: Associated with Left Heart Disease
1Division of Cardiovascular Disease, Pulmonary Hypertension Program, Advanced Heart Failure, LVAD and Transplantation Program, The Ohio State University, DHLRI Suite 200, 473 West 12th Avenue, Columbus, OH 43210, USA.
Abstract:
Pulmonary hypertension (PH) due to left heart disease, or WHO group 2 PH, is the most frequent cause of PH. It affects approximately 50% to 60% of patients with heart failure with preserved ejection fraction as well as 60% of those with heart failure with reduced ejection fraction and contributes significantly to disease progression and unfavorable outcomes. The diagnosis of PH is associated with poor prognosis and significant morbidity and mortality.
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