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5HT-1A receptor polymorphism effects ejaculatory function in Egyptian patients with lifelong premature ejaculation
Mohamed Farid Roaiah1, Yasser Ibrahim Elkhayat1, Laila Ahmed Rashed1
1Andrology & STDs Department, Cairo University, Egypt.
Revista Internacional De Andrologia
|September 30, 2018
Summary
A specific gene polymorphism in the 5HT-1A receptor was significantly associated with lifelong premature ejaculation (LPE). This finding supports the role of genetic factors in LPE, offering potential insights for future research and treatment strategies.
Area of Science:
- Genetics
- Urology
- Reproductive Health
Background:
- Lifelong premature ejaculation (LPE) affects patients and partners, causing distress and intimacy avoidance.
- A potential role for the (HTR1A)-C (1019) G gene polymorphism in LPE has been recently suggested.
Purpose of the Study:
- To investigate the association between 5HT-1A receptor gene polymorphisms and lifelong premature ejaculation.
- To determine if specific gene variants correlate with intra-vaginal ejaculation latency time (IELT) in LPE patients.
Main Methods:
- Prospective enrollment of 350 participants (245 LPE patients, 105 controls) from an Andrology & STDs clinic.
- Measurement of intra-vaginal ejaculation latency time (IELT) by partners during the first intercourse for one month.
- Genotyping performed to analyze the (HTR1A)-C (1019) G gene polymorphism.
Main Results:
- A statistically significant association (p<0.001) was observed between CG genotype in patients and GG genotype in controls.
- Highly significant statistical association found between the studied gene polymorphisms and IELT in LPE cases (p=0.001).
Conclusions:
- The study confirms a significant association between 5HT-1A receptor gene polymorphisms and lifelong premature ejaculation.
- These findings reinforce the potential genetic underpinnings of LPE, warranting further investigation.
Keywords:
5HT1A receptor gene polymorphismEyaculación precoz permanenteLifelong premature ejaculationPolimorfismo del gen del receptor de 5-HT1AMore Related Videos
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