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Updated: Feb 4, 2026

Computer-Generated Animal Model Stimuli
Published on: July 29, 2007
[Rickets/Osteomalacia. Vitamin D action:Lessons from animal models.]
1Nagasaki University Graduate School of Biomedical Sciences, Japan.
Abstract:
Animal studies using mice model such as vitamin D deficiency and global and conditional VDR knock out(KO)mice have disclosed that the physiological role of vitamin D strongly depends on the calcium balance. Vitamin D stimulates active intestinal calcium transport mechanism, thereby maintains normocalcemia that has priority over skeletal integrity. Besides the biological significance of vitamin D extensively studied, its precise function in non-classical target needs further investigation.
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