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Updated: Feb 4, 2026

Minimal Erythema Dose MED Testing
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Minimal Erythema Dose MED Testing

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Erythema nodosum.

Alexander K C Leung1, Kin Fon Leong2, Joseph M Lam3

  • 1Department of Pediatrics, The Alberta Children's Hospital, The University of Calgary, #200, 233-16th Avenue NW, Calgary, AB, T2M 0H5, Canada. aleung@ucalgary.ca.

World Journal of Pediatrics : WJP
|October 1, 2018
PubMed
Summary
This summary is machine-generated.

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Erythema nodosum presents as painful nodules, often linked to systemic diseases. Pediatricians should evaluate, diagnose, and treat this condition, considering underlying causes.

Area of Science:

  • Dermatology
  • Pediatrics
  • Internal Medicine

Background:

  • Erythema nodosum is a systemic disease with limited pediatric literature.
  • This condition presents as painful, subcutaneous nodules.

Purpose of the Study:

  • To familiarize pediatricians with the evaluation, diagnosis, and treatment of erythema nodosum.
  • To highlight the association of erythema nodosum with various systemic conditions.

Main Methods:

  • A PubMed search was conducted using the key term "erythema nodosum" in Clinical Queries.
  • Diagnosis is primarily clinical, with biopsy reserved for atypical presentations.

Main Results:

  • Erythema nodosum manifests as sudden-onset, painful, erythematous nodules, typically on the pretibial areas, often bilateral and symmetrical.
Keywords:
Drug-inducedGroup A β-hemolytic streptococcal infectionSarcoidosisSubcutaneous pretibial nodulesTuberculosisYersinia infection

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  • Associated conditions include infections, medications, sarcoidosis, inflammatory bowel disease, autoimmune diseases, and malignancy; approximately 50% of cases are idiopathic.
  • Recommended initial laboratory screening includes CBC, ESR/CRP, throat swab, ASO titers, and chest radiograph, with further tests guided by clinical findings.
  • Most cases are self-limited, with management focusing on rest, leg elevation, and NSAIDs for pain.

    • Conclusions:

    • Erythema nodosum is frequently a cutaneous sign of an underlying systemic disease.
    • A comprehensive investigation is crucial to identify the root cause of erythema nodosum.