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Non-tubercular caseous adenopathy in Senegal
S Diadie1, M Ndiaye1, B A Diatta1
1Service de dermatologie, hôpital Aristide LeDantec, 3001 Dakar, Sénégal.
African histoplasmosis, caused by Histoplasma capsulatum var duboisii, was diagnosed in a young man with skin lesions, enlarged lymph nodes, spleen, and liver. This case highlights the importance of mycologic and histologic examination for diagnosing this fungal infection.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Dermatology
Background:
- African histoplasmosis is a deep fungal infection caused by Histoplasma capsulatum var duboisii.
- It primarily affects the skin, lymph nodes, and reticuloendothelial system.
Observation:
- A 22-year-old man presented with a seven-month history of papulo-nodular skin lesions.
- Physical examination revealed lymphadenopathy, splenomegaly, and hepatomegaly.
Findings:
- Mycologic and histologic examination of skin lesions confirmed Histoplasma capsulatum var duboisii.
- Biopsied lymph nodes showed caseous changes.
- Fungal culture on Lowenstein-Jensen medium yielded negative results.
Implications:
- This case underscores the diagnostic utility of direct mycologic and histologic examination in suspected cases of African histoplasmosis.
- Early diagnosis and appropriate management are crucial for better patient outcomes.
- Further research into the epidemiology and treatment of this fungal infection is warranted.
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