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Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
Published on: August 13, 2019
Analysis of bone healing with a novel bone wax substitute compared with bone wax in a porcine bone defect model
Tristan Tham1,1, Keith Roberts2,2, John Shanahan2,2
1New York Head & Neck Institute, Lenox Hill Hospital, New York, NY, 10075, USA.
Aim:
This pilot study describes a novel composite of hydroxyapatite and biodegradable polylactic acid with wax-like handling properties (BoneSeal®). The goal was to compare quantitative measures of bone healing between BoneSeal versus Bone wax.
Materials & Methods:
BoneSeal and Bone wax were introduced into separate defects of a single porcine specimen. After 6 weeks, the defect sites were harvested for analysis.
Results:
Both groups had similar hemostatic action. The amount of new bone was significantly greater at 6 weeks in the BoneSeal group (38.05%) versus the Bone wax group (11.88%), p = 0.028.
Conclusion:
In this pilot study, BoneSeal had higher amounts of new bone formation compared with Bone wax.
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