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Long-Term Treatment and Survival in Three Apparently Immunocompetent Dogs with Disseminated Fungal Infection Caused

Marlene Townsell1, Alfred M Legendre1, David A Bemis1

  • 1From VCA Advanced Veterinary Care Center, Lawndale, California (M.T.); The University of Tennessee College of Veterinary Medicine, Knoxville, Tennessee (A.M.L., D.A.B.); Auburn University College of Veterinary Medicine, Auburn, Alabama (E.B.); and CARE Veterinary Center, Frederick, Maryland (S.P.).

Journal of the American Animal Hospital Association
|October 2, 2018
PubMed

Insights

Disseminated fungal infections in dogs can be serious. This study shows that Phialosimplex caninus infections improved with antifungal drugs like itraconazole, with some dogs achieving long-term remission.

Area of Science:

  • Veterinary Mycology
  • Canine Infectious Diseases

Background:

  • Disseminated fungal infections pose a significant threat to canine health, with varying prognoses based on the causative agent.
  • Phialosimplex caninus, a recently identified hyalohyphomyces, has limited documented clinical information regarding its course in dogs.

Observation:

  • This study details the clinical presentation, diagnostic data, therapeutic responses, and outcomes for three dogs diagnosed with disseminated P. caninus.
  • The dogs presented with clinical signs consistent with systemic fungal disease.

Findings:

  • Treatment with itraconazole, optionally combined with terbinafine, led to improved quality of life in all affected dogs.
  • One dog achieved long-term remission of the P. caninus infection even after antifungal therapy was discontinued.

Implications:

  • Antifungal therapy, particularly with itraconazole, appears effective for managing disseminated P. caninus infections in dogs.
  • Further research into P. caninus is warranted to better understand its pathogenesis and optimize treatment strategies for improved long-term outcomes in canine patients.

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