[BIOMARKERS OF EARLY AND DIFFERENTIAL DIAGNOSIS OF PROSTATIC CANCER]

There were examined 87 patients, suffering prostatic gland diseases, in whom the level of general prostate-specific antigen (PSA) in the blood have constituted 0.5 – 30 ng/ml. In 27 of them prostatic gland diseases were not revealed, in 28 – prostatic cancer was diagnosed, and in 32 – benign prostatic hyperplasia. There was proved, that rate of prostatic cancer and benign prostatic hyperplasia have correlated with prostatic gland volume and depended upon PSA and its isoforms concentration in the blood. The [-2] proPSA in the blood serum level have differed in all three groups, and the level of general and free PSA – in patients of group I, comparing with that in the groups 2 and 3. That have witnessed the possibility of determining of the [-2]proPSA content as alternative biomarker of early and differential diagnosis of prostatic cancer.