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Enema of Traditional Chinese Medicine for Patients with Severe Acute Pancreatitis
Published on: January 27, 2023
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[CORRECTION OF INTRAABDOMINAL PRESSURE IN RATS IN AN ACUTE PANCREATITIS, USING INFUSION OF MYORELAXANT OF A DURABLE
Klinichna Khirurhiia
|October 2, 2018
Summary
Pipecuronium bromide effectively reduced intraabdominal pressure in rats with experimentally induced purulent pancreatitis. This myorelaxant demonstrates potential for treating intraabdominal hypertension in similar conditions.
Area of Science:
- Pharmacology
- Critical Care Medicine
- Surgical Research
Background:
- Intraabdominal hypertension (IAH) is a serious complication.
- Purulent pancreatitis can lead to significant increases in intraabdominal pressure (IAP).
- Effective management of IAH is crucial for patient outcomes.
Purpose of the Study:
- To investigate the effect of pipecuronium bromide on IAP.
- To assess the efficacy of this myorelaxant in a model of acute peritonitis and purulent pancreatitis.
- To evaluate its role in managing experimentally induced IAH.
Main Methods:
- Acute peritonitis and purulent pancreatitis were induced in rats using L-arginine.
- Intraabdominal pressure (IAP) was measured in experimental and control groups.
- The impact of pipecuronium bromide administration on IAP was analyzed.
Main Results:
- Rats with induced purulent pancreatitis exhibited a 4.5-fold increase in IAP compared to controls (p < 0.001).
- Pipecuronium bromide administration resulted in a 33.4% reduction in IAP.
- The myorelaxant demonstrated a significant hypotensive effect in this model.
Conclusions:
- Pipecuronium bromide shows efficacy in lowering elevated IAP.
- Myorelaxants are potentially valuable in managing intraabdominal hypertension associated with purulent pancreatitis.
- This study supports the use of pipecuronium bromide in treating IAH in critical care settings.
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