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Herpesvirus Infections of the Nervous System
Continuum (Minneapolis, Minn.)
|October 2, 2018
Summary
Human herpesvirus infections can cause severe neurologic disease, especially in immunosuppressed patients. Early diagnosis and treatment are crucial for better outcomes.
Area of Science:
- Neurology
- Infectious Diseases
- Virology
Background:
- Human herpesvirus infections are increasingly prevalent, particularly in immunocompromised individuals.
- Historically, herpes simplex virus (HSV) encephalitis was the primary concern, but other herpesviruses now recognized for neurologic impact include varicella-zoster virus (VZV), Epstein-Barr virus (EBV), cytomegalovirus (CMV), and human herpesvirus 6 (HHV-6).
- Clinical presentations are diverse, affecting various parts of the central and peripheral nervous systems.
Purpose of the Study:
- To review the spectrum of neurologic diseases caused by human herpesvirus infections.
- To detail the pathophysiology, epidemiology, clinical presentations, diagnostics, imaging, and treatment of these infections.
Main Methods:
- Literature review of neurologic diseases associated with human herpesvirus infections.
- Discussion of diagnostic and therapeutic advancements.
Main Results:
- Herpesvirus family infections can lead to severe neurologic complications if not treated promptly.
- Advanced diagnostic tools are available for specific herpesviruses.
- Emerging data highlight viral resistance to conventional therapies, necessitating consideration of newer antiviral agents.
Conclusions:
- Prompt clinical recognition and advanced testing are essential for accurate diagnosis of herpesvirus-related neurologic disease.
- Understanding secondary complications is vital for preventing mortality and morbidity.
- Comprehensive knowledge of HSV-1, HSV-2, VZV, EBV, CMV, and HHV-6 neurologic infections guides effective management.
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