[МОRPHOLOGY OF THE DIABETIC FOOT SYNDROME]

Area of Science:

• Medical research
• Diabetology
• Wound healing

Background:

• Diabetic foot syndrome (DFS) is a significant complication of diabetes mellitus.
• Effective local treatment is crucial for managing DFS and preventing complications.
• Understanding dynamic morphological changes during treatment is key to optimizing care.

Purpose of the Study:

• To investigate the dynamic local morphological changes in patients with diabetic foot syndrome.
• To evaluate the efficacy of standard local treatment protocols on wound healing in DFS.
• To correlate histological findings with clinical treatment progression.

Main Methods:

• Study included 215 patients diagnosed with diabetic foot syndrome.
• Local treatment was administered according to established clinical standards.
• Histological investigations of wound biopsies were performed dynamically throughout the treatment period.

Main Results:

• Adequate local treatment led to a reduction in edema, cellular infiltration, and microcirculatory disorders at the wound boundary.
• Within one week, biopsies revealed young granulation tissue characterized by numerous perpendicular vascular loops and fibroblast bundles.
• By two weeks, active multilayered epithelization was observed, with the stratum creeps securing the wound surface.

Conclusions:

• Standardized local treatment protocols are effective in managing diabetic foot syndrome.
• Histological dynamics demonstrate rapid and organized wound healing processes, including granulation and epithelization.
• The study confirms the successful application of local treatment standards for achieving timely wound closure in DFS.