Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glucose Transporters01:27

Glucose Transporters

27.5K
Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
27.5K
Overview of Systemic and Pulmonary Circulation01:15

Overview of Systemic and Pulmonary Circulation

11.0K
The systemic and pulmonary circuits are crucial components of the circulatory system, working together to transport blood between the heart, lungs, and the rest of the body. The process begins with pulmonary circulation, where deoxygenated blood is pumped from the right ventricle to the lungs via the pulmonary trunk and arteries. Upon reaching the lungs, the blood becomes oxygenated and returns to the heart, specifically to the left atrium, via the pulmonary veins.
The oxygenated blood is sent...
11.0K
Secondary Active Transport01:55

Secondary Active Transport

137.9K
One example of how cells use the energy contained in electrochemical gradients is demonstrated by glucose transport into cells. The ion vital to this process is sodium (Na+), which is typically present in higher concentrations extracellularly than in the cytosol. Such a concentration difference is due, in part, to the action of an enzyme “pump” embedded in the cellular membrane that actively expels Na+ from a cell. Importantly, as this pump contributes to the high concentration of...
137.9K
Accessory Structures of the Skin: Sweat Glands01:20

Accessory Structures of the Skin: Sweat Glands

3.8K
Sweat glands or sudoriferous glands are one of the important accessory structures of the skin. They are small, coiled tubular structures located in the dermis, the middle layer of the skin. Sweat glands are responsible for producing and secreting sweat, a watery fluid that helps regulate body temperature and excrete waste products.
Sweat glands are classified as merocrine glands; that is, the secretions are excreted by exocytosis through a duct without affecting the cells of the gland. There...
3.8K
Gas Exchange and Transport01:20

Gas Exchange and Transport

77.0K
Gas exchange, the intake of molecular oxygen (O2) from the environment and the outflow of carbon dioxide (CO2) into the environment, is necessary for cellular function. Gas exchange during respiration occurs largely via the movement of gas molecules along pressure gradients. Gas travels from areas of higher partial pressure to areas of lower partial pressure. In mammals, gas exchange occurs in the alveoli of the lungs, which are adjacent to capillaries and share a membrane with them.
77.0K
Glucose Homeostasis: Regulation of Blood Glucose01:02

Glucose Homeostasis: Regulation of Blood Glucose

4.3K
Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
4.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Protein Binding and Molecular Size Govern Molecular Transport into Dermal Interstitial Fluid.

ACS sensors·2026
Same author

Does slowly reversible binding to keratin contribute to stratum corneum reservoir function?

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2025
Same author

Investigation of effects of collection conditions on amino acid concentrations in sweat and correlations with their Circulating levels in plasma.

Scientific reports·2025
Same author

Are lateral lipid-phase diffusion coefficients pertinent to dermal absorption?

Journal of controlled release : official journal of the Controlled Release Society·2025
Same author

Discretised microfluidics for noninvasive health monitoring using sweat sensing.

Lab on a chip·2024
Same author

Impact of solvent dry down, phase change, vehicle pH and slowly reversible keratin binding on skin penetration of cosmetic relevant compounds: II. Solids.

International journal of pharmaceutics·2024

Related Experiment Video

Updated: Feb 4, 2026

A Simple Flow Cytometric Method to Measure Glucose Uptake and Glucose Transporter Expression for Monocyte Subpopulations in Whole Blood
06:28

A Simple Flow Cytometric Method to Measure Glucose Uptake and Glucose Transporter Expression for Monocyte Subpopulations in Whole Blood

Published on: August 12, 2016

17.3K

Modeling Glucose Transport From Systemic Circulation to Sweat.

Terri D La Count1, Andrew Jajack2, Jason Heikenfeld2

  • 1Division of Pharmaceutical Sciences, James L Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio 45267.

Journal of Pharmaceutical Sciences
|October 2, 2018
PubMed
Summary

Developing a mathematical model for sweat glucose estimation, this study shows potential for noninvasive blood biomarker monitoring. The model accurately represents glucose transport from blood to sweat, aiding future biosensor development.

Keywords:
biomarkersglucosemathematical modelsensorsweat

More Related Videos

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
18:57

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers

Published on: October 17, 2013

47.4K
Determination of the Transport Rate of Xenobiotics and Nanomaterials Across the Placenta using the ex vivo Human Placental Perfusion Model
08:08

Determination of the Transport Rate of Xenobiotics and Nanomaterials Across the Placenta using the ex vivo Human Placental Perfusion Model

Published on: June 18, 2013

17.9K

Related Experiment Videos

Last Updated: Feb 4, 2026

A Simple Flow Cytometric Method to Measure Glucose Uptake and Glucose Transporter Expression for Monocyte Subpopulations in Whole Blood
06:28

A Simple Flow Cytometric Method to Measure Glucose Uptake and Glucose Transporter Expression for Monocyte Subpopulations in Whole Blood

Published on: August 12, 2016

17.3K
Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
18:57

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers

Published on: October 17, 2013

47.4K
Determination of the Transport Rate of Xenobiotics and Nanomaterials Across the Placenta using the ex vivo Human Placental Perfusion Model
08:08

Determination of the Transport Rate of Xenobiotics and Nanomaterials Across the Placenta using the ex vivo Human Placental Perfusion Model

Published on: June 18, 2013

17.9K

Area of Science:

  • Biomedical Engineering
  • Physiological Modeling

Background:

  • Noninvasive monitoring of blood biomarkers is desirable.
  • Sweat sensing presents a promising, yet challenging, avenue for estimating blood analyte levels.

Purpose of the Study:

  • To develop and validate a physiologically based transport model for estimating blood glucose from sweat glucose.
  • To assess the feasibility of sweat sensing for noninvasive glucose monitoring.

Main Methods:

  • Simultaneous measurement of iontophoretically stimulated sweat glucose and fasted blood glucose in human subjects.
  • Utilized a novel prototype sweat collection/analysis system and a commercial glucometer.
  • Calibrated a dynamic mathematical model using experimental data and published studies.

Main Results:

  • The model accurately represented sweat glucose values under various physiological conditions.
  • A blood-to-sweat lag time of 10 minutes was identified.
  • The sweat/blood glucose ratio ranged from 0.001 to 0.02, dependent on sweat rate.

Conclusions:

  • The developed model satisfactorily describes the sweat-to-blood glucose relationship.
  • This algorithm can facilitate the development of advanced sweat biosensors for noninvasive monitoring.