Related Experiment Video

Updated: Aug 18, 2026

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
15:49

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

Published on: October 17, 2013

Clinical disease activity and endoscopic severity correlate poorly in children newly diagnosed with Crohn's disease

Nicholas Carman1, Diane Tomalty2, Peter C Church2

  • 1Children's Hospital of Eastern Ontario, Department of Pediatrics, University of Ottawa, Ottawa, Canada.

Gastrointestinal Endoscopy
|October 2, 2018
PubMed

Insights

In pediatric Crohn's disease, the weighted Pediatric Crohn's Disease Activity Index (wPCDAI) poorly reflects endoscopic severity. Clinical markers alone are insufficient for assessing disease activity in children with newly diagnosed Crohn's disease.

Area of Science:

  • Pediatric Gastroenterology
  • Inflammatory Bowel Disease Research
  • Clinical Trial Analysis

Background:

  • Crohn's disease (CD) treatment increasingly targets mucosal healing.
  • Noninvasive measures to assess mucosal healing in pediatric CD require validation.
  • Limited data exist on the correlation between clinical indices and endoscopic findings in pediatric CD.

Purpose of the Study:

  • To compare endoscopic disease severity with the weighted Pediatric Crohn's Disease Activity Index (wPCDAI) in children with newly diagnosed CD.
  • To evaluate the utility of clinical indices and biochemical markers in reflecting endoscopic disease activity.

Main Methods:

  • Inclusion of 280 children (≤17 years) newly diagnosed with CD from the Canadian Children Inflammatory Bowel Disease Network.
  • Assessment of clinical disease activity using wPCDAI and biochemical parameters.
  • Evaluation of endoscopic severity via the Simple Endoscopic Score for CD (SES-CD) and correlation analysis with clinical and biochemical markers.

Main Results:

  • A weak correlation was observed between wPCDAI and SES-CD (r = 0.39, P < .001).
  • Most wPCDAI components, except stooling, showed weak correlation with SES-CD.
  • Routine blood tests did not correlate well with endoscopic severity, and clinical symptoms primarily explained disease activity variations.

Conclusions:

  • The wPCDAI demonstrates poor correlation with endoscopic disease activity in newly diagnosed pediatric Crohn's disease.
  • Clinical markers alone should not be relied upon to determine disease activity, especially as treatment goals shift towards mucosal healing.
Abstract

More Related Videos

Induction of Intestinal Graft-versus-host Disease and Its Mini-endoscopic Assessment in Live Mice09:50

Induction of Intestinal Graft-versus-host Disease and Its Mini-endoscopic Assessment in Live Mice

Published on: February 11, 2019

A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease05:08

A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease

Published on: March 1, 2022

Related Concept Videos

Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies01:28

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...