Electrospun mucosal wound dressings containing styptics for bleeding control

Area of Science:

• Biomaterials Science
• Regenerative Medicine
• Otorhinolaryngology

Background:

• Mucosal wound healing presents challenges in otorhinolaryngology due to limited surgical access and dressing fixation.
• Existing treatments often lack the ability to support hemostasis, a critical factor for optimal healing.

Purpose of the Study:

• To develop an innovative mucosal wound dressing that addresses application difficulties and supports hemostasis.
• To create a biocompatible, adaptable dressing for diverse mucosal defect sizes and locations.

Main Methods:

• Fabrication of an electrospun poly(l-lactide-co-d/l-lactide) (PLA) material.
• Loading the PLA fabric with hemostatic agents: adrenaline and tranexamic acid.
• Evaluation of biocompatibility, flexibility, and hemostatic efficacy in simulated mucosal defects.

Main Results:

• The developed PLA electrospun fabrics are biocompatible, thin, and flexible, allowing for tailored application to mucosal defects.
• The loaded dressings demonstrated a faster and time-controlled hemostatic reaction.
• Significant improvement in the mucosal wound healing process was observed.

Conclusions:

• The novel PLA-based wound dressing effectively supports hemostasis and accelerates mucosal healing.
• This technology offers a promising solution for otorhinolaryngological applications, overcoming previous limitations in dressing application and stability.