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06:01
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
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Thrombotic Microangiopathies with Rheumatologic Involvement.
1Division of Renal Diseases and Hypertension, Department of Medicine, George Washington University, 2150 Pennsylvania Avenue, Washington, DC 20037, USA.
Rheumatic Diseases Clinics of North America
|October 3, 2018
Summary
This review explores renal thrombotic microangiopathy in rheumatologic diseases. Systemic lupus erythematosus is a common cause, alongside scleroderma renal crisis and antiphospholipid antibody syndrome.
Area of Science:
- Nephrology
- Rheumatology
- Hematology
Background:
- Thrombotic microangiopathies (TM) are complex conditions causing anemia, low platelets, and kidney damage.
- Causes are diverse, including metabolic, infectious, medication-related, complement, pregnancy, malignancy, and autoimmune factors.
Purpose of the Study:
- To review the specific causes and clinical features of renal thrombotic microangiopathy within the context of rheumatologic diseases.
- To highlight the association between TM and autoimmune conditions.
Main Methods:
- Literature review focusing on thrombotic microangiopathy and rheumatologic conditions.
- Analysis of case reports and existing studies.
Main Results:
- Systemic lupus erythematosus is the most frequent autoimmune disease linked to TM.
- Scleroderma renal crisis and antiphospholipid antibody syndrome are significant causes, often secondary to autoimmune diseases.
- TM has been reported in rheumatoid arthritis and dermatomyositis.
Conclusions:
- Rheumatologic diseases represent a critical category of causes for renal thrombotic microangiopathy.
- Early recognition and management of TM in rheumatologic patients are essential for renal outcomes.
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