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Replicability of Introgression Under Linked, Polygenic Selection.

Himani Sachdeva1, Nicholas H Barton2

  • 1Institute of Science and Technology Austria, A-3400 Klosterneuburg, Austria.

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Summary
This summary is machine-generated.

Genomic introgression under selection is influenced by linked loci, not just individual effects. This study reveals how linked gene blocks impact trait introgression and adaptation.

Keywords:
Hill–Robertson interferenceintrogressionpolygenic adaptation

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Area of Science:

  • Population Genetics
  • Evolutionary Biology
  • Genomics

Background:

  • Understanding how advantageous genetic material spreads through a population is crucial for evolutionary studies.
  • Directional selection drives adaptation, but the process is complex in the presence of multiple genes.

Purpose of the Study:

  • To investigate the introgression dynamics of a large genomic block containing numerous weakly selected loci under directional selection.
  • To determine how linked loci influence the introgression rate and probability of individual variants within the block.

Main Methods:

  • Derivation of exact mathematical expressions for the expected growth rate of genomic fragments during initial introgression.
  • Analysis of the relationship between fragment growth rate and long-term introgression probability.
  • Individual-based simulations to explore the impact of fitness effect variance, block fitness, and population size.

Main Results:

  • The growth rate of a single locus variant is dependent on the combined effects of linked loci within a characteristic linkage scale, rather than its own additive effect.
  • Expected fragment growth rate strongly correlates with long-term introgression probability, enabling identification of likely introgressing variants.
  • Introgression probability is shaped by hitchhiking effects and fine-scale selection within fragments, leading to differential introgression of beneficial and deleterious loci over time.

Conclusions:

  • The introgression of genomic blocks is a complex process influenced by the collective effects of linked loci.
  • This linkage-based introgression mechanism complicates the identification of specific causal loci underlying polygenic adaptation, even for highly repeatable evolutionary events.