Related Experiment Video
Updated: Feb 4, 2026
10:28
Body Composition and Metabolic Caging Analysis in High Fat Fed Mice
Published on: May 24, 2018
16.4K
Changes in body composition and metabolic disease risk
1Columbia University College of Physicians and Surgeons and Columbia Institute of Human Nutrition, New York, NY, USA. fxp1@columbia.edu.
European Journal of Clinical Nutrition
|October 3, 2018
Summary
Weight gain leads to fat accumulation, causing ectopic fat deposition. This increases the risk of insulin resistance, metabolic syndrome, type 2 diabetes, and cardiovascular disease, which weight loss can mitigate.
Area of Science:
- Metabolic health
- Obesity research
- Endocrinology
Background:
- Weight gain causes adipocyte enlargement and fat accrual.
- Ectopic fat accumulates in visceral, muscle, liver, and beta cell depots.
- Ectopic fat disrupts insulin-sensitive tissues.
Purpose of the Study:
- To explain the link between weight gain, ectopic fat, and metabolic dysfunction.
- To highlight the risks associated with ectopic fat deposition.
- To underscore the benefits of weight loss in mitigating these risks.
Main Methods:
- Review of physiological processes related to fat accumulation.
- Analysis of the impact of ectopic fat on metabolic pathways.
- Correlation of fat deposition with disease risk factors.
Main Results:
- Adipocyte enlargement and ectopic fat deposition are consequences of weight gain.
- Ectopic fat initiates dysfunctional states in insulin-sensitive tissues.
- Insulin resistance, metabolic syndrome, type 2 diabetes, and cardiovascular disease risk increase with ectopic fat.
Conclusions:
- Ectopic fat accumulation is a key driver of metabolic dysfunction.
- Weight loss reduces ectopic fat and mitigates associated health risks.
- Managing body fat is crucial for preventing metabolic diseases.
More Related Videos
Related Concept Videos
00:55Composite Bodies
1.4K
A composite body is a body made up of multiple parts, connected to form a larger, unified object. Each part has its own weight and center of gravity, which must be considered to determine the center of gravity of the composite body. In cases where the density or specific weight is constant, the center of gravity coincides with the centroid.
Composite bodies have widespread applications in mechanical engineering, from automobiles to aircraft to rockets. For example, an automobile wheel comprises...
Composite bodies have widespread applications in mechanical engineering, from automobiles to aircraft to rockets. For example, an automobile wheel comprises...
1.4K
01:29Composition of Body Fluids
2.6K
Water functions as a solvent accommodating various solutes, which can be categorized under electrolytes and non-electrolytes. Non-electrolytes are usually held together by covalent bonds, restricting them from dissociating in solution, thereby leading to a lack of electrically charged components upon dissolving in water. They are predominantly organic molecules, such as glucose, creatinine, and urea. Electrolytes, on the other hand, are compounds that can break down into ions in water.
2.6K
01:25Metabolic States of the Body: The Absorptive State
1.7K
During the absorptive state, which lasts approximately four hours after a meal, the body absorbs nutrients from the gastrointestinal tract. The carbohydrates, proteins, and lipids we consume are broken down into monosaccharides, amino acids, and free fatty acids for absorption. While carbohydrates and proteins are absorbed as-is, lipids are absorbed in their broken-down forms and then re-esterified into triglycerides within enterocytes before being packaged into chylomicrons. These absorbed...
1.7K
01:18Metabolic States of the Body: The Postabsorptive State
1.4K
The postabsorptive state usually starts about four hours after a meal and lasts until the next meal is eaten. During this time, the digestive system stops absorbing nutrients, and the body uses stored energy reserves to maintain stable blood glucose levels.
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...
1.4K
01:24Metabolic States of the Body: Fasting and Starvation
2.9K
During the initial hours of fasting, the body uses up its glycogen stores as an energy source. Once these glycogen reserves are depleted, the body begins breaking down stored triglycerides and structural proteins. During this stage, glycerol becomes a key substrate for gluconeogenesis, while free fatty acids undergo beta-oxidation to provide energy for tissues, such as skeletal muscle. In the fasting state, the body spares protein breakdown as much as possible to conserve muscle and structural...
2.9K
00:52What is Metabolism?
131.9K
Overview
131.9K